Amanda Heslegrave
Overview
Explore the profile of Amanda Heslegrave including associated specialties, affiliations and a list of published articles.
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113
Citations
2398
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Recent Articles
1.
Berger M, Garcia-Moreno H, Ferreira M, Hubener-Schmid J, Schaprian T, Wegner P, et al.
medRxiv
. 2025 Feb;
PMID: 39974031
Background: Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited adult-onset disease. We aimed to describe longitudinal changes in clinical and biological findings and to identify predictors for clinical...
2.
Cipriani S, Porrello E, Cerea M, Gazzaniga A, Di Guardo R, Heslegrave A, et al.
Brain Commun
. 2025 Feb;
7(1):fcaf039.
PMID: 39926607
Charcot-Marie-Tooth (CMT) neuropathies represent a broad and very heterogeneous group of disorders for which no therapies are yet available. Due to the huge genetic heterogeneity, therapeutical approaches that can benefit...
3.
Carrol D, Busse W, Frye C, Klaus D, Bach J, Floerke H, et al.
Brain Behav Immun
. 2025 Feb;
126:80-97.
PMID: 39921150
Introduction: Chronic systemic inflammation is highly prevalent and has deleterious effects on the brain, impacting both function and structure, and manifesting in elevations in psychological symptoms transdiagnostically. Asthma is a...
4.
Duff E, Zetterberg H, Heslegrave A, Dehghan A, Elliott P, Allen N, et al.
Nat Med
. 2025 Jan;
PMID: 39885359
Previous studies have suggested that systemic viral infections may increase risks of dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections is unknown. Determining...
5.
McKeever A, Swann P, Malpetti M, Donaghy P, Thomas A, Mak E, et al.
Alzheimers Dement
. 2025 Jan;
21(2):e14381.
PMID: 39853853
Introduction: Lewy body dementia (LBD) shares genetic risk factors with Alzheimer's disease (AD), including apolipoprotein E (APOE), but is distinguishable at the genome-wide level. Polygenic risk scores (PRS) may therefore...
6.
Scahill R, Farag M, Murphy M, Hobbs N, Leocadi M, Langley C, et al.
Nat Med
. 2025 Jan;
PMID: 39825149
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease with the age at which characteristic symptoms manifest strongly influenced by inherited HTT CAG length. Somatic CAG expansion occurs throughout life...
7.
Kodosaki E, Bell R, Sogorb-Esteve A, Wiltshire K, Zetterberg H, Heslegrave A
Front Neurosci
. 2024 Nov;
18:1499458.
PMID: 39544911
The role of myeloid cells (granulocytes and monocytes) in neurodegeneration and neurodegenerative disorders (NDD) is indisputable. Here we discuss the roles of myeloid cells in neurodegenerative diseases, and the recent...
8.
Al-Diwani A, Provine N, Murchison A, Laban R, Swann O, Koychev I, et al.
Brain
. 2024 Oct;
148(2):394-400.
PMID: 39432679
In animal models, brain neurodegeneration biomarkers drain into cervical lymph nodes (CLNs), and this drainage function is reduced with ageing. If this occurred in humans, CLNs may provide a readily...
9.
Tsui A, Johnstone B, Heslegrave A, Zetterberg H, Watne L, Neerland B, et al.
Brain Commun
. 2024 Oct;
6(5):fcae319.
PMID: 39355007
Delirium is associated with the risk of future long-term cognitive impairment, but the degree to which markers of neuronal injury may be distinct or shared with dementia has yet to...
10.
Li L, Kodosaki E, Heslegrave A, Zetterberg H, Graham N, Zimmerman K, et al.
Brain
. 2024 Sep;
148(3):1015-1030.
PMID: 39323289
Pathophysiology and outcomes after traumatic brain injury (TBI) are complex and heterogeneous. Current classifications are uninformative about pathophysiology. Proteomic approaches with fluid-based biomarkers are ideal for exploring complex disease mechanisms,...