Amanda Heslegrave
Overview
Explore the profile of Amanda Heslegrave including associated specialties, affiliations and a list of published articles.
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113
Citations
2398
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Recent Articles
11.
Monica C, Revell V, Atzori G, Laban R, Skene S, Heslegrave A, et al.
Transl Psychiatry
. 2024 Sep;
14(1):373.
PMID: 39271655
Plasma biomarkers of dementia, including phosphorylated tau (p-tau217), offer promise as tools for diagnosis, stratification for clinical trials, monitoring disease progression, and assessing the success of interventions in those living...
12.
Li Y, Luo L, Senicar L, Asrosa R, Kizilates B, Xing K, et al.
Adv Healthc Mater
. 2024 Sep;
13(30):e2401966.
PMID: 39221506
Accurate assessment of neurological disease through monitoring of biomarkers has been made possible using the antibody-based assays. But these assays suffer from expensive development of antibody probes, reliance on complicated...
13.
Alagaratnam J, Stohr W, Hamlyn E, Porter K, Toombs J, Heslegrave A, et al.
J Virus Erad
. 2024 Jul;
10(2):100381.
PMID: 38988673
Objective: Antiretroviral therapy (ART)-conferred suppression of HIV replication limits neuronal injury and inflammation. ART interruption tests efficacy in HIV cure trials and viral rebound after ART interruption may induce neuronal...
14.
Reichert Plaska C, Heslegrave A, Bruno D, Ramos-Cejudo J, Lee S, Osorio R, et al.
Brain Behav Immun
. 2024 May;
120():248-255.
PMID: 38795783
Major depressive disorder (MDD) is associated with Alzheimer's disease (AD) but the precise mechanisms underlying this relationship are not understood. While it is well established that cerebrospinal fluid (CSF) soluble...
15.
Leckey C, Coulton J, Giovannucci T, He Y, Aslanyan A, Laban R, et al.
Brain Commun
. 2024 May;
6(3):fcae132.
PMID: 38707707
Neurofilament light chain is an established marker of neuroaxonal injury that is elevated in CSF and blood across various neurological diseases. It is increasingly used in clinical practice to aid...
16.
Swift I, Rademakers R, Finch N, Baker M, Ghidoni R, Benussi L, et al.
Alzheimers Res Ther
. 2024 Mar;
16(1):66.
PMID: 38539243
Background: Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has...
17.
Perino J, Patterson M, Momen M, Borisova M, Heslegrave A, Zetterberg H, et al.
Am J Vet Res
. 2024 Feb;
85(4).
PMID: 38382190
Objective: The aim of this study was to investigate whether plasma neurofilament light chain (pNfL) concentration was altered in Labrador Retrievers with idiopathic laryngeal paralysis (ILP) compared to a control...
18.
Carroll A, Razvi Y, ODonnell L, Veleva E, Heslegrave A, Zetterberg H, et al.
Amyloid
. 2024 Feb;
31(2):95-104.
PMID: 38348665
Background: Neurofilament light chain (NfL) has emerged as a sensitive biomarker in hereditary transthyretin amyloid polyneuropathy (ATTRv-PN). We hypothesise that NfL can identify conversion of gene carriers to symptomatic disease,...
19.
Schuldt A, Bern H, Hart M, Gompels M, Winston A, Clarke A, et al.
Viruses
. 2024 Jan;
16(1).
PMID: 38275937
The aim of this study is to identify the factors associated with peripheral neuropathy and to explore neurofilament light chain (NfL) as a biomarker for peripheral neuropathy (PN) in effectively...
20.
Quartesan I, Vegezzi E, Curro R, Heslegrave A, Pisciotta C, Iruzubieta P, et al.
Mov Disord
. 2023 Dec;
39(1):209-214.
PMID: 38054570
Background: Biallelic intronic AAGGG repeat expansions in the replication factor complex subunit 1 (RFC1) gene were identified as the leading cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome. Patients exhibit...