Jamie Toombs
Overview
Explore the profile of Jamie Toombs including associated specialties, affiliations and a list of published articles.
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34
Citations
792
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Recent Articles
1.
Alagaratnam J, Stohr W, Hamlyn E, Porter K, Toombs J, Heslegrave A, et al.
J Virus Erad
. 2024 Jul;
10(2):100381.
PMID: 38988673
Objective: Antiretroviral therapy (ART)-conferred suppression of HIV replication limits neuronal injury and inflammation. ART interruption tests efficacy in HIV cure trials and viral rebound after ART interruption may induce neuronal...
2.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, et al.
Acta Neuropathol
. 2024 Feb;
147(1):32.
PMID: 38319380
Synapse loss correlates with cognitive decline in Alzheimer's disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of...
3.
Willumsen N, Arber C, Lovejoy C, Toombs J, Alatza A, Weston P, et al.
Brain Commun
. 2023 Jan;
5(1):fcac321.
PMID: 36687397
Mutations in the presenilin 1 gene, which cause familial Alzheimer's disease alter the processing of amyloid precursor protein, leading to the generation of various amyloid-β peptide species. These species differ...
4.
King D, Holt K, Toombs J, He X, Dando O, Okely J, et al.
Alzheimers Dement
. 2022 Dec;
19(6):2560-2574.
PMID: 36547260
Introduction: It remains unclear why age increases risk of Alzheimer's disease and why some people experience age-related cognitive decline in the absence of dementia. Here we test the hypothesis that...
5.
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, et al.
Brain Neurosci Adv
. 2022 Apr;
6:23982128221086464.
PMID: 35359460
Synapse loss is associated with cognitive decline in Alzheimer's disease, and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta around amyloid plaques...
6.
Austin K, Lee B, Flood T, Toombs J, Borisova M, Lauder M, et al.
Sci Med Footb
. 2022 Jan;
5(3):188-194.
PMID: 35077291
: To investigate if heading frequency and impact biomechanics in a single session influence the concentration of serum neurofilament light (NF-L), a sensitive biomarker for axonal damage, up to 7 ...
7.
Alagaratnam J, De Francesco D, Zetterberg H, Heslegrave A, Toombs J, Kootstra N, et al.
J Neurovirol
. 2021 Dec;
28(1):54-63.
PMID: 34874540
Cerebrospinal fluid (CSF) neurofilament light protein (NfL) is a marker of central nervous system neuro-axonal injury. A novel, ultra-sensitive assay can determine plasma NfL. In untreated people-with-HIV (PWH), CSF and...
8.
Alagaratnam J, Stohr W, Toombs J, Heslegrave A, Zetterberg H, Gisslen M, et al.
J Virus Erad
. 2021 Oct;
7(3):100056.
PMID: 34611495
Objective: HIV-remission strategies including kick-and-kill could induce viral transcription and immune-activation in the central nervous system, potentially causing neuronal injury. We investigated the impact of kick-and-kill on plasma neurofilament light...
9.
Banerjee G, Forsgard N, Ambler G, Keshavan A, Paterson R, Foiani M, et al.
J Neurol
. 2021 Jul;
269(3):1470-1475.
PMID: 34292397
Introduction: Cerebral amyloid angiopathy (CAA) is associated with symptomatic intracerebral haemorrhage. Biomarkers of clinically silent bleeding events, such as cerebrospinal fluid (CSF) ferritin and iron, might provide novel measures of...
10.