Aly A Hazzaa
Overview
Explore the profile of Aly A Hazzaa including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
79
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with proof
El-Miligy M, Al-Kubeisi A, Nassra R, El-Zemity S, Hazzaa A
J Enzyme Inhib Med Chem
. 2024 Jan;
39(1):2309171.
PMID: 38291670
New thymol-3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds , , , and displayed inhibitory activity against COX-2 (IC= 0.037, 0.042, 0.046, and 0.039 µM nearly equal to celecoxib...
2.
Abdelaziz M, El-Miligy M, Fahmy S, Abu-Serie M, Hazzaa A, Mahran M
J Enzyme Inhib Med Chem
. 2024 Jan;
39(1):2304044.
PMID: 38230430
New aromatic -alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. and showed potent anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and...
3.
El-Miligy M, Abdelaziz M, Fahmy S, Ibrahim T, Abu-Serie M, Mahran M, et al.
J Enzyme Inhib Med Chem
. 2023 Jan;
38(1):2152810.
PMID: 36629075
New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds , , , and showed low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent anticancer...
4.
El-Miligy M, Al-Kubeisi A, Bekhit M, El-Zemity S, Nassra R, Hazzaa A
J Enzyme Inhib Med Chem
. 2022 Nov;
38(1):294-308.
PMID: 36408833
New thymol - 1,5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds , , and displayed inhibitory activity against COX-2 (IC= 0.043, 0.045, 0.063, and 0.068 µM nearly equal to...
5.
El-Miligy M, Al-Kubeisi A, El-Zemity S, Nassra R, Abu-Serie M, Hazzaa A
Bioorg Chem
. 2021 Jul;
115:105171.
PMID: 34303896
Colorectal cancer (CRC) is the second cause of cancer death worldwide. Inhibitors of COX-2, 5-LOX and PIM-1 kinase were very effective in the treatment and prevention of CRC in mouse...
6.
Omar A, Abd El Razik H, Hazzaa A, El-Attar M, El Demellawy M, Abdel Wahab A, et al.
Future Med Chem
. 2019 Aug;
11(13):1583-1603.
PMID: 31469327
Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Sulfanylpyrimidines and triazolopyrimidines were synthesized and evaluated as anticancer and antioxidant COX-1/2 inhibitors. Compound showed the same growth...
7.
Abdelaziz M, El-Miligy M, Fahmy S, Mahran M, Hazzaa A
Bioorg Chem
. 2018 Aug;
80:674-692.
PMID: 30064079
A series of pyridine and thieno[2,3-b]pyridine derivatives have been designed and synthesized as anticancer PIM-1 kinase inhibitors. Thirty-seven compounds were selected by NCI to be tested initially at a single...
8.
El-Miligy M, Hazzaa A, El-Messmary H, Nassra R, M El-Hawash S
Bioorg Chem
. 2017 Apr;
72:102-115.
PMID: 28390993
New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors. The benzothiophene or benzofuran scaffold was linked at position -2 with rhodanine...
9.
El-Miligy M, Hazzaa A, El-Messmary H, Nassra R, El-Hawash S
Future Med Chem
. 2017 Apr;
9(5):443-468.
PMID: 28362117
Aim: Simultaneous inhibition of 5-LOX/COX may enhance anti-inflammatory effects and reduce side effects. Hence, synthesis of novel dual inhibitors of 5-LOX/COX is an important strategy for treatment of inflammation. Results/methodology:...
10.
Rida S, M El-Hawash S, Fahmy H, Hazzaa A, El-Meligy M
Arch Pharm Res
. 2006 Nov;
29(10):826-33.
PMID: 17121175
Previously, we synthesized and evaluated several benzofuran derivatives containing heterocyclic ring substituents linked to the benzofuran nucleus at C-2 by a two- to four-atom spacer as potential anti-HIV-1, anticancer and...