Nadeeja Wijesekara
Overview
Explore the profile of Nadeeja Wijesekara including associated specialties, affiliations and a list of published articles.
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25
Citations
1446
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Recent Articles
1.
Fioriti L, Wijesekara N, Argyrousi E, Matsuzaki S, Takamura H, Satoh K, et al.
Alzheimers Dement
. 2025 Mar;
21(3):e70030.
PMID: 40047257
Introduction: Amyloid beta oligomers (Aβos) are toxic to synapses and key to the progression of Alzheimer's disease (AD) and amyloid pathology, representing a target for therapeutic strategies. Methods: Amyloid and...
2.
Wijesekara N, Ahrens R, Wu L, Langman T, Tandon A, Fraser P
Front Aging Neurosci
. 2021 Aug;
13:665348.
PMID: 34393754
Aim: Population based studies indicate a positive association between type 2 diabetes (T2D) and Parkinson's disease (PD) where there is an increased risk of developing PD in patients with T2D....
3.
Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro A, Song Y, et al.
JCI Insight
. 2021 May;
6(10).
PMID: 34027899
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to...
4.
Wijesekara N, Goncalves R, Ahrens R, Ha K, De Felice F, Fraser P
J Pathol
. 2021 Apr;
254(3):244-253.
PMID: 33797777
Amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau are important contributors to Alzheimer's disease (AD). Tau also impacts pancreatic beta cell function and glucose homeostasis. Amyloid deposits composed of...
5.
Goncalves R, Wijesekara N, Fraser P, De Felice F
Front Endocrinol (Lausanne)
. 2020 Apr;
11:124.
PMID: 32226410
Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to...
6.
Goncalves R, Wijesekara N, Fraser P, De Felice F
Front Cell Neurosci
. 2019 Feb;
13:17.
PMID: 30804755
The microtubule-associated protein tau (MAPT) is mainly identified as a tubulin binding protein essential for microtubule dynamics and assembly and for neurite outgrowth. However, several other possible functions for Tau...
7.
Wijesekara N, Goncalves R, Ahrens R, De Felice F, Fraser P
FASEB J
. 2018 Feb;
32(6):3166-3173.
PMID: 29401605
The microtubule-associated protein tau is highly expressed in pancreatic islets. Abnormally phosphorylated tau aggregates assemble into neurofibrillary tangles linked to Alzheimer's disease pathology and has also been found in islets...
8.
Wijesekara N, Goncalves R, De Felice F, Fraser P
Neuropharmacology
. 2017 Nov;
136(Pt B):172-181.
PMID: 29169962
Alzheimer's disease (AD) is the most common type of dementia. Recent studies suggest that metabolic disturbances, particularly type 2 diabetes (T2D) increase the risk of cognitive decline and AD. AD...
9.
Laws S, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser P, et al.
Sci Rep
. 2017 Aug;
7(1):9766.
PMID: 28852028
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can...
10.
Wijesekara N, Ahrens R, Sabale M, Wu L, Ha K, Verdile G, et al.
FASEB J
. 2017 Aug;
31(12):5409-5418.
PMID: 28808140
Alzheimer's disease (AD) and type 2 diabetes (T2D) present a significant risk to each other. AD and T2D are characterized by deposition of cerebral amyloid-β (Aβ) and pancreatic human islet...