Alfonso Valencia
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Explore the profile of Alfonso Valencia including associated specialties, affiliations and a list of published articles.
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375
Citations
22243
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Recent Articles
11.
Parra R, Freiberger M, Poley-Gil M, Fernandez-Martin M, Radusky L, Ruiz-Serra V, et al.
Nucleic Acids Res
. 2024 Apr;
52(W1):W233-W237.
PMID: 38587198
According to the Principle of Minimal Frustration, folded proteins can only have a minimal number of strong energetic conflicts in their native states. However, not all interactions are energetically optimized...
12.
Ruiz-Serra V, Valentini S, Madronero S, Valencia A, Porta-Pardo E
Bioinformatics
. 2024 Apr;
40(4).
PMID: 38565273
Motivation: The interpretation of genomic data is crucial to understand the molecular mechanisms of biological processes. Protein structures play a vital role in facilitating this interpretation by providing functional context...
13.
Serra F, Nieto-Aliseda A, Fanlo-Escudero L, Rovirosa L, Cabrera-Pasadas M, Lazarenkov A, et al.
Nat Commun
. 2024 Apr;
15(1):2821.
PMID: 38561401
Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms by which p53 controls gene transcription are not completely understood....
14.
Avila-Nieto C, Vergara-Alert J, Amengual-Rigo P, Ainsua-Enrich E, Brustolin M, Rodriguez de la Concepcion M, et al.
Nat Commun
. 2024 Mar;
15(1):2349.
PMID: 38514609
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of...
15.
Nunez-Carpintero I, Rigau M, Bosio M, OConnor E, Spendiff S, Azuma Y, et al.
Nat Commun
. 2024 Feb;
15(1):1227.
PMID: 38418480
Exploring the molecular basis of disease severity in rare disease scenarios is a challenging task provided the limitations on data availability. Causative genes have been described for Congenital Myasthenic Syndromes...
16.
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie M, et al.
Front Immunol
. 2024 Feb;
14:1282859.
PMID: 38414974
Introduction: The COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop...
17.
Nikolski M, Hovig E, Al-Shahrour F, Blomberg N, Scollen S, Valencia A, et al.
Nat Cancer
. 2024 Feb;
5(3):367-372.
PMID: 38321342
No abstract available.
18.
Boutros M, Baumann M, Bigas A, Chaabane L, Guerin J, Habermann J, et al.
Cancer Discov
. 2024 Jan;
14(1):30-35.
PMID: 38213296
To enable a collective effort that generates a new level of UNderstanding CANcer (UNCAN.eu) [Cancer Discov (2022) 12 (11): OF1], the European Union supports the creation of a sustainable platform...
19.
Barajas A, Amengual-Rigo P, Pons-Grifols A, Ortiz R, Carmona O, Urrea V, et al.
J Transl Med
. 2024 Jan;
22(1):14.
PMID: 38172991
Background: Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens has evolved with...
20.
Avila-Nieto C, Vergara-Alert J, Amengual-Rigo P, Ainsua-Enrich E, Brustolin M, Rodriguez de la Concepcion M, et al.
Front Immunol
. 2023 Dec;
14:1291972.
PMID: 38124756
Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the development of...