Alexis L Norris
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Explore the profile of Alexis L Norris including associated specialties, affiliations and a list of published articles.
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18
Citations
543
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Recent Articles
11.
Nucifora L, MacDonald M, Lee B, Peters M, Norris A, Orsburn B, et al.
Am J Psychiatry
. 2019 May;
176(9):730-743.
PMID: 31055969
Objective: The mechanisms leading to schizophrenia are likely to be diverse. However, there may be common pathophysiological pathways for subtypes of the disease. The authors tested the hypothesis that increased...
12.
Debeljak M, Noe M, Riel S, Haley L, Norris A, Anderson D, et al.
Mol Diagn Ther
. 2018 Jul;
22(5):603-611.
PMID: 29974360
Background: Ultrasensitive detection of low-abundance DNA point mutations is a challenging molecular biology problem, because nearly identical mutant and wild-type molecules exhibit crosstalk. Reliable ultrasensitive point mutation detection will facilitate...
13.
Jaffe A, Tao R, Norris A, Kealhofer M, Nellore A, Shin J, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(27):7130-7135.
PMID: 28634288
RNA sequencing (RNA-seq) is a powerful approach for measuring gene expression levels in cells and tissues, but it relies on high-quality RNA. We demonstrate here that statistical adjustment using existing...
14.
Lee B, Marchionni L, Andrews C, Norris A, Nucifora L, Wu Y, et al.
Schizophr Res
. 2017 Jan;
185:58-66.
PMID: 28038920
Clozapine is the only medication indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents, but its mechanism of action is poorly understood. To date, no...
15.
Norris A, Workman R, Fan Y, Eshleman J, Timp W
Cancer Biol Ther
. 2016 Jan;
17(3):246-53.
PMID: 26787508
Despite advances in sequencing, structural variants (SVs) remain difficult to reliably detect due to the short read length (<300 bp) of 2nd generation sequencing. Not only do the reads (or...
16.
Roberts N, Norris A, Petersen G, Bondy M, Brand R, Gallinger S, et al.
Cancer Discov
. 2015 Dec;
6(2):166-75.
PMID: 26658419
Unlabelled: Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2020. A familial aggregation of pancreatic cancer has been established, but...
17.
Norris A, Kamiyama H, Makohon-Moore A, Pallavajjala A, Morsberger L, Lee K, et al.
Genes Chromosomes Cancer
. 2015 Jun;
54(8):472-481.
PMID: 26031834
Pancreatic ductal adenocarcinoma (PDAC) is driven by the inactivation of the tumor suppressor genes (TSGs), CDKN2A (P16) and SMAD4 (DPC4), commonly by homozygous deletions (HDs). Using a combination of high...
18.
Eshleman J, Norris A, Sadakari Y, Debeljak M, Borges M, Harrington C, et al.
Clin Gastroenterol Hepatol
. 2014 Dec;
13(5):963-9.e4.
PMID: 25481712
Background & Aims: Pancreatic imaging can identify neoplastic cysts but not microscopic neoplasms. Mutation analysis of pancreatic fluid after secretin stimulation might identify microscopic neoplasias in the pancreatic duct system....
19.
Norris A, Roberts N, Jones S, Wheelan S, Papadopoulos N, Vogelstein B, et al.
Fam Cancer
. 2014 Sep;
14(1):95-103.
PMID: 25240578
Pancreatic ductal adenocarcinoma (PDAC) is nearly uniformly lethal, with a median overall survival in 2014 of only 6 months. The genetic progression of sporadic PDAC (SPC) is well established, with...
20.
Matthaei H, Norris A, Tsiatis A, Olino K, Hong S, Dal Molin M, et al.
Ann Surg
. 2011 Dec;
255(2):326-33.
PMID: 22167000
Objective: To examine the clinicopathologic features and clonal relationship of multifocal intraductal papillary mucinous neoplasms (IPMNs) of the pancreas. Background: Intraductal papillary mucinous neoplasms are increasingly diagnosed cystic precursor lesions...