Winston Timp
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Explore the profile of Winston Timp including associated specialties, affiliations and a list of published articles.
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100
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5911
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Recent Articles
1.
Mahlke M, Lumerman L, Nath P, Chittenden C, Hoyt S, Koeppel J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975122
Centromere location is specified by CENP-A, a centromere-specific histone that epigenetically propagates centromere identity. How CENP-A is epigenetically maintained at one location in rapidly evolving centromeric DNA is unknown. Using...
2.
Grossman N, Fan Y, Zimin A, Wear M, Jedlicka A, Dziedzic A, et al.
bioRxiv
. 2025 Feb;
PMID: 39896459
is a fungal pathogen responsible for serious, often fatal, illness in patients with compromised immune systems. Treatment is rarely successful because is inherently resistant to all major classes of antifungal...
3.
Morina L, Cao H, Chen S, Kumar S, McFarland K, Majewska N, et al.
J Biotechnol
. 2025 Jan;
399:91-98.
PMID: 39824362
Chinese Hamster Ovary (CHO) cells produce monoclonal antibodies and other biotherapeutics at industrial scale. Despite their ubiquitous nature in the biopharmaceutical industry, little is known about the behaviors of individual...
4.
Volkel K, Hook P, Keung A, Timp W, Tuck J
Bioinformatics
. 2025 Jan;
41(1).
PMID: 39777456
Motivation: As nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long...
5.
Billingsley K, Meredith M, Daida K, Jerez P, Negi S, Malik L, et al.
bioRxiv
. 2025 Jan;
PMID: 39764002
Structural variants (SVs) drive gene expression in the human brain and are causative of many neurological conditions. However, most existing genetic studies have been based on short-read sequencing methods, which...
6.
Saba J, Huang Z, Schole K, Ye X, Bhatt S, Li Y, et al.
EMBO J
. 2024 Nov;
43(24):6555-6572.
PMID: 39533057
Terminal oligopyrimidine motif-containing mRNAs (TOPs) encode all ribosomal proteins in mammals and are regulated to tune ribosome synthesis to cell state. Previous studies have implicated LARP1 in 40S- or 80S-ribosome...
7.
Lin K, Volkel K, Cao C, Hook P, Polak R, Clark A, et al.
Nat Nanotechnol
. 2024 Aug;
19(11):1654-1664.
PMID: 39174834
Any modern information system is expected to feature a set of primordial features and functions: a substrate stably carrying data; the ability to repeatedly write, read, erase, reload and compute...
8.
Nickels T, Gale A, Harrington A, Timp W, Cunningham K
G3 (Bethesda)
. 2024 Jul;
14(9).
PMID: 39047065
Candida glabrata (also called Nakaseomyces glabratus) is an opportunistic pathogen that can resist common antifungals and rapidly acquire multidrug resistance. A large amount of genetic variation exists between isolates, which...
9.
Anantharam R, Duchen D, Cox A, Timp W, Thomas D, Clipman S, et al.
Viruses
. 2024 May;
16(5).
PMID: 38793605
Routinely used metagenomic next-generation sequencing (mNGS) techniques often fail to detect low-level viremia (<10 copies/mL) and appear biased towards viruses with linear genomes. These limitations hinder the capacity to comprehensively...
10.
Nickels T, Gale A, Harrington A, Timp W, Cunningham K
bioRxiv
. 2024 May;
PMID: 38746084
Summary: Candida glabrata is an emerging pathogen with large genetic diversity and genome plasticity. The type strain CBS138 and a laboratory derivative were mutagenized with the transposon and profiled using...