Alexi J C Sarris
Overview
Explore the profile of Alexi J C Sarris including associated specialties, affiliations and a list of published articles.
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8
Citations
93
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0
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Recent Articles
1.
Torres-Garcia D, van de Plassche M, van Boven E, van Leeuwen T, Groenewold M, Sarris A, et al.
RSC Chem Biol
. 2022 Nov;
3(11):1325-1330.
PMID: 36349224
Bioorthogonal chemistry combines well with activity-based protein profiling, as it allows for the introduction of detection tags without significantly influencing the physiochemical and biological functions of the probe. In this...
2.
de Boer C, Armstrong Z, Lit V, Barash U, Ruijgrok G, Boyango I, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(31):e2203167119.
PMID: 35881786
Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the extracellular matrix (ECM), providing signals that regulate cellular growth and development. Altered HSPG composition during tumorigenesis strongly aids cancer progression. Heparanase...
3.
Bertheussen K, van de Plassche M, Bakkum T, Gagestein B, Ttofi I, Sarris A, et al.
Angew Chem Int Ed Engl
. 2022 Jul;
61(38):e202207640.
PMID: 35838324
In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising biological properties arising from detectable pendant groups....
4.
de Geus M, Maurits E, Sarris A, Hansen T, Kloet M, Kamphorst K, et al.
Chemistry
. 2020 Mar;
26(44):9900-9904.
PMID: 32154603
The inverse electron demand Diels-Alder pyridazine elimination reaction between tetrazines and allylic substituted trans-cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of...
5.
Sarris A, Hansen T, de Geus M, Maurits E, Doelman W, Overkleeft H, et al.
Chemistry
. 2018 Sep;
24(68):18075-18081.
PMID: 30184286
The inverse-electron-demand Diels-Alder/pyridazine elimination tandem reaction, in which the allylic substituent on trans-cyclooctene is eliminated following reaction with tetrazines, is gaining interest as a versatile bioorthogonal process. One potential shortcoming...
6.
van der Gracht A, de Geus M, Camps M, Ruckwardt T, Sarris A, Bremmers J, et al.
ACS Chem Biol
. 2018 May;
13(6):1569-1576.
PMID: 29733186
Activation of a cytotoxic T-cell is a complex multistep process, and tools to study the molecular events and their dynamics that result in T-cell activation in situ and in vivo...
7.
Bakkum T, van Leeuwen T, Sarris A, van Elsland D, Poulcharidis D, Overkleeft H, et al.
ACS Chem Biol
. 2018 Apr;
13(5):1173-1179.
PMID: 29693370
One of the areas in which bioorthogonal chemistry-chemistry performed inside a cell or organism-has become of pivotal importance is in the study of host-pathogen interactions. The incorporation of bioorthogonal groups...
8.
Liu W, Keizers P, Hass M, Blok A, Timmer M, Sarris A, et al.
J Am Chem Soc
. 2012 Sep;
134(41):17306-13.
PMID: 22994925
Paramagnetic lanthanides ions are broadly used in NMR spectroscopy. The effects of unpaired electrons on NMR spectral parameters provide a powerful tool for the characterization of macromolecular structures and dynamics....