Thomas Bakkum
Overview
Explore the profile of Thomas Bakkum including associated specialties, affiliations and a list of published articles.
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13
Citations
80
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0
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Recent Articles
1.
Zeng Y, Shen M, Pattipeiluhu R, Zhou X, Zhang Y, Bakkum T, et al.
Nanoscale
. 2023 Sep;
15(37):15206-15218.
PMID: 37671560
Gene delivery has great potential in modulating protein expression in specific cells to treat diseases. Such therapeutic gene delivery demands sufficient cellular internalization and endosomal escape. Of various nonviral nucleic...
2.
Bertheussen K, van de Plassche M, Bakkum T, Gagestein B, Ttofi I, Sarris A, et al.
Angew Chem Int Ed Engl
. 2022 Jul;
61(38):e202207640.
PMID: 35838324
In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising biological properties arising from detectable pendant groups....
3.
Nami F, Ferraz M, Bakkum T, Aerts J, Pandit A
Angew Chem Int Ed Engl
. 2022 Feb;
61(14):e202117521.
PMID: 35103372
Non-invasive and real-time recording of processes in living cells has been limited to detection of small cellular components such as soluble proteins and metabolites. Here we report a multiphase NMR...
4.
van Leeuwen T, Araman C, Pieper Pournara L, Kampstra A, Bakkum T, Marqvorsen M, et al.
RSC Chem Biol
. 2021 Jul;
2(3):855-862.
PMID: 34212151
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof...
5.
Ignacio B, Bakkum T, Bonger K, Martin N, van Kasteren S
Org Biomol Chem
. 2021 Mar;
19(13):2856-2870.
PMID: 33725048
Bacterial infections are still one of the leading causes of death worldwide; despite the near-ubiquitous availability of antibiotics. With antibiotic resistance on the rise, there is an urgent need for...
6.
Andrian T, Bakkum T, van Elsland D, Bos E, Koster A, Albertazzi L, et al.
Methods Cell Biol
. 2021 Mar;
162:303-331.
PMID: 33707017
Correlative light and electron microscopy (CLEM) entails a group of multimodal imaging techniques that are combined to pinpoint to the location of fluorescently labeled molecules in the context of their...
7.
Shen M, Olsthoorn R, Zeng Y, Bakkum T, Kros A, Boyle A
ACS Appl Mater Interfaces
. 2021 Mar;
13(10):11621-11630.
PMID: 33656313
Magnetic-activated cell sorting (MACS) is an affinity-based technique used to separate cells according to the presence of specific markers. Current MACS systems generally require an antigen to be expressed at...
8.
van Dalen F, Bakkum T, van Leeuwen T, Groenewold M, Deu E, Koster A, et al.
Front Chem
. 2021 Mar;
8:628433.
PMID: 33644004
Cathepsin S is a lysosomal cysteine protease highly expressed in immune cells such as dendritic cells, B cells and macrophages. Its functions include extracellular matrix breakdown and cleavage of cell...
9.
Bakkum T, Heemskerk M, Bos E, Groenewold M, Oikonomeas-Koppasis N, Walburg K, et al.
ACS Cent Sci
. 2020 Dec;
6(11):1997-2007.
PMID: 33274277
Bioorthogonal correlative light-electron microscopy (B-CLEM) can give a detailed overview of multicomponent biological systems. It can provide information on the ultrastructural context of bioorthogonal handles and other fluorescent signals, as...
10.
Voorneveld J, Florea B, Bakkum T, Mendowicz R, van der Veer M, Gagestein B, et al.
Chembiochem
. 2020 Apr;
21(17):2431-2434.
PMID: 32282108
The poly-ADP-ribose polymerase (PARP) is a protein from the family of ADP-ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to sites of...