Alexey B Dyatkin
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Explore the profile of Alexey B Dyatkin including associated specialties, affiliations and a list of published articles.
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11
Citations
31
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Recent Articles
1.
Breslin H, Diamond C, Kavash R, Cai C, Dyatkin A, Miskowski T, et al.
Bioorg Med Chem Lett
. 2012 Jun;
22(14):4869-72.
PMID: 22695132
A small set of acyclic analogs 5 were prepared to explore their structure-activity relationships (SARs) relative to heterocyclic core, opioid receptor (OR) agonists 4. Compound 5l was found to have...
2.
Ralbovsky J, Lisko J, Palmer J, Mabus J, Chevalier K, Schulz M, et al.
Bioorg Med Chem Lett
. 2009 Apr;
19(10):2661-3.
PMID: 19375913
A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue.
3.
Gong Y, Barbay J, Kimball E, Santulli R, Carolyn Fisher M, Dyatkin A, et al.
Bioorg Med Chem Lett
. 2008 Jan;
18(4):1331-5.
PMID: 18226905
Structural modification and cellular adhesion inhibition activities of pyridazinone-substituted phenylalanine amide alpha(4) integrin antagonists are described. Functionality requirements for the arylamide moiety and the carboxylic acid group were demonstrated. The...
4.
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
Gong Y, Barbay J, Dyatkin A, Miskowski T, Kimball E, Prouty S, et al.
J Med Chem
. 2006 May;
49(11):3402-11.
PMID: 16722660
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions. Concise syntheses were developed and applied for exploration...
5.
Lawson E, Santulli R, Dyatkin A, Ballentine S, Abraham W, Rudman S, et al.
Bioorg Med Chem
. 2006 Feb;
14(12):4208-16.
PMID: 16495061
The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for...
6.
Dyatkin A, Gong Y, Miskowski T, Kimball E, Prouty S, Carolyn Fisher M, et al.
Bioorg Med Chem
. 2005 Aug;
13(24):6693-702.
PMID: 16112583
A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of alpha4beta1-VCAM-1 and alpha4beta7-MAdCAM-1 interactions. Potency and alpha4beta1/alpha4beta7 selectivity were sensitive to the substituent R1-R3...
7.
Matthews J, Hoekstra W, Dyatkin A, Hecker L, Hlasta D, Poulter B, et al.
Bioorg Med Chem Lett
. 2004 May;
14(11):2747-52.
PMID: 15125926
Vasopressin receptor antagonists can elicit ion-sparing diuretic effects (i.e., aquaresis) in vivo by blunting the action of the circulating hypophyseal hormone arginine vasopressin. We have identified two new series of...
8.
Dyatkin A, Hoekstra W, Kinney W, Kontoyianni M, Santulli R, Kimball E, et al.
Bioorg Med Chem Lett
. 2004 Jan;
14(3):591-6.
PMID: 14741249
The design, synthesis, and biological activity of novel alpha(4)beta(1) and alpha(4)beta(7) integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and...
9.
Dyatkin A, Hoekstra W, Hlasta D, Andrade-Gordon P, de Garavilla L, Demarest K, et al.
Bioorg Med Chem Lett
. 2002 Oct;
12(21):3081-4.
PMID: 12372506
The synthesis and biological testing of a novel series of nonpeptide vasopressin receptor antagonists, containing a bridged bicyclic nucleus, are reported. Variation of substituents (R(1)-R(3)) in general formula 3, and...
10.
Dyatkin A, Freedman T, Cao X, Dukor R, Maryanoff B, Maryanoff C, et al.
Chirality
. 2002 Feb;
14(2-3):215-9.
PMID: 11835568
We present the results of a study using vibrational circular dichroism (VCD) for (+)-1, which furnished an unambiguous determination of its absolute configuration as S. The most abundant conformation of...