Dennis J Hlasta
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Explore the profile of Dennis J Hlasta including associated specialties, affiliations and a list of published articles.
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18
Citations
37
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Recent Articles
1.
Matthews J, Chen X, Cryan E, Hlasta D, Rybczynski P, Strauss K, et al.
Bioorg Med Chem Lett
. 2007 Nov;
17(24):6773-8.
PMID: 18029176
A series of aminoindane derivatives were synthesized and shown to be potent PPARalpha agonists. The compounds were obtained as racemates in 12 steps, and tested for PPARalpha activation and PPARalpha...
2.
Berry C, Zificsak C, Gibbs A, Hlasta D
Org Lett
. 2007 Sep;
9(21):4099-102.
PMID: 17854191
Thiazolium azomethine ylides, equipped with a C-2 methanethiol group, participate in an efficient [3 + 2] cycloaddition reaction with acetylene derivatives to yield unique pyrrolo[2,1-b]thiazoles. The elimination of the methanethiol...
3.
Paget S, Boggs C, Foleno B, Goldschmidt R, Hlasta D, Weidner-Wells M, et al.
Bioorg Med Chem Lett
. 2006 Jun;
16(17):4537-42.
PMID: 16806921
A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
4.
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists
Gong Y, Barbay J, Dyatkin A, Miskowski T, Kimball E, Prouty S, et al.
J Med Chem
. 2006 May;
49(11):3402-11.
PMID: 16722660
A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions. Concise syntheses were developed and applied for exploration...
5.
Coats S, Link J, Gauthier D, Hlasta D
Org Lett
. 2005 Apr;
7(8):1469-72.
PMID: 15816729
[reaction: see text] A regioselective method for the preparation of 1,5-trisubstituted 1H-1,2,3-triazoles via a 1,3-dipolar cycloaddition of 1-trimethylsilylacetylenes with organoazides is described. Immobilization of the azide on REM resin and...
6.
Coats S, Schulz M, Carson J, Codd E, Hlasta D, Pitis P, et al.
Bioorg Med Chem Lett
. 2004 Oct;
14(22):5493-8.
PMID: 15482911
Two parallel synthetic methods were developed to explore the structure-activity relationships (SAR) of a series of potent opioid agonists. This series of tropanylidene benzamides proved extremely tolerant of structural variation...
7.
Coats S, Schulz M, Hlasta D
J Comb Chem
. 2004 Sep;
6(5):688-91.
PMID: 15360200
No abstract available.
8.
Henninger T, Xu X, Abbanat D, Baum E, Foleno B, Hilliard J, et al.
Bioorg Med Chem Lett
. 2004 Sep;
14(17):4495-9.
PMID: 15357979
A new series of antibacterial ketolides is reported, which features the use of a C-6 carbamate for tethering the arylalkyl sidechain to the macrolide core. The best members of this...
9.
Schulz M, Coats S, Hlasta D
Org Lett
. 2004 Sep;
6(19):3265-8.
PMID: 15355028
[reaction: see text] The addition of azido trimethylsilane to arylnitrileboronate esters is shown to proceed rapidly in dimethoxyethane to give aryltetrazoleboronate esters in moderate to good yields, with dibutyltin oxide...
10.
Weidner-Wells M, Henninger T, Fraga-Spano S, Boggs C, Matheis M, Ritchie D, et al.
Bioorg Med Chem Lett
. 2004 Jul;
14(16):4307-11.
PMID: 15261292
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8...