Alexandra Mazharian
Overview
Explore the profile of Alexandra Mazharian including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
33
Citations
791
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mazharian A, Senis Y
Mol Cell Biol
. 2025 Feb;
45(3):116-128.
PMID: 39991916
Platelets, or thrombocytes are anucleate cell fragments of megakaryocytes (MKs) that are highly reactive to sites of vascular injury and implicated in many pathologies. However, the molecular mechanisms regulating the...
2.
Smith C, Nagy Z, Geer M, Pike J, Patel P, Senis Y, et al.
Res Pract Thromb Haemost
. 2024 Sep;
8(6):102557.
PMID: 39318773
Background: Inhibition of platelet responsiveness is important for controlling thrombosis. It is well established that platelet endothelial cell adhesion molecule-1 (PECAM-1) serves as a physiological negative regulator of platelet-collagen interactions....
3.
Mazharian A, Bertin O, Sarkar A, Augros J, Bornert A, Loubiere C, et al.
bioRxiv
. 2024 May;
PMID: 38798354
Platelets are highly reactive fragments of megakaryocytes that play a fundamental role in thrombosis and hemostasis. Predictably, all conventional anti-platelet therapies elicit bleeding, raising the question whether the thrombotic activity...
4.
Carminita E, Tourn J, Crescence L, Brouilly N, Merrill-Skoloff G, Mazharian A, et al.
Res Pract Thromb Haemost
. 2023 Dec;
7(7):102209.
PMID: 38077809
Background: The contribution of platelets in thrombosis within microcirculation has been extensively documented in the literature. We previously showed, , that platelet activation revealed by intracellular calcium mobilization was a...
5.
Mazharian A, Maitre B, Bornert A, Hennequin D, Lourenco-Rodrigues M, Geer M, et al.
Blood Adv
. 2022 Oct;
7(1):46-59.
PMID: 36269841
Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expansion of...
6.
Stavnichuk M, Tauer J, Nagy Z, Mazharian A, Welman M, Lordkipanidze M, et al.
J Bone Miner Res
. 2021 Jan;
36(4):803-813.
PMID: 33434328
Patients with chronic myelofibrosis often suffer from osteosclerosis, which is associated with bone pain and may lead to bone marrow failure. The pathogenesis of myelofibrosis is linked to aberrant megakaryocyte...
7.
Nagy Z, Mori J, Ivanova V, Mazharian A, Senis Y
Blood
. 2020 Feb;
135(18):1574-1587.
PMID: 32016283
The Src family kinases (SFKs) Src, Lyn, and Fyn are essential for platelet activation and also involved in megakaryocyte (MK) development and platelet production. Platelet SFKs are inhibited by C-terminal...
8.
Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions
Bellio M, Garcia C, Edouard T, Voisin S, Neel B, Cabou C, et al.
Blood
. 2019 Sep;
134(25):2304-2317.
PMID: 31562133
Src homology 2 domain-containing phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a ubiquitous protein tyrosine phosphatase that is a critical regulator of signal transduction. Germ line mutations in...
9.
Vogtle T, Sharma S, Mori J, Nagy Z, Semeniak D, Scandola C, et al.
Elife
. 2019 Aug;
8.
PMID: 31436532
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and...
10.
Kumawat K, Geerdink R, Hennus M, Roda M, Van Ark I, Leusink-Muis T, et al.
Front Immunol
. 2019 May;
10:842.
PMID: 31080449
Neutrophils are crucial to antimicrobial defense, but excessive neutrophilic inflammation induces immune pathology. The mechanisms by which neutrophils are regulated to prevent injury and preserve tissue homeostasis are not completely...