Alexandra Mazharian
Overview
Explore the profile of Alexandra Mazharian including associated specialties, affiliations and a list of published articles.
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33
Citations
791
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Recent Articles
11.
Nagy Z, Vogtle T, Geer M, Mori J, Heising S, Di Nunzio G, et al.
Blood
. 2018 Nov;
133(4):331-343.
PMID: 30429161
Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The () transgenic mouse is the current model of choice for generating megakaryocyte/platelet-specific KO mice. Platelets...
12.
Boraschi-Diaz I, Mort J, Bromme D, Senis Y, Mazharian A, Komarova S
Bone
. 2018 Sep;
117:23-30.
PMID: 30217615
The major organic component of bone is collagen type I. Osteoclasts are terminally differentiated multinucleated cells of hematopoietic origin that are essential for physiological development of bone and teeth. We...
13.
Smith C, Raslan Z, Parfitt L, Khan A, Patel P, Senis Y, et al.
Blood Adv
. 2018 Aug;
2(16):2072-2078.
PMID: 30120105
No abstract available.
14.
Hofmann I, Geer M, Vogtle T, Crispin A, Campagna D, Barr A, et al.
Blood
. 2018 Jun;
132(13):1399-1412.
PMID: 29898956
Unlike primary myelofibrosis (PMF) in adults, myelofibrosis in children is rare. Congenital (inherited) forms of myelofibrosis (cMF) have been described, but the underlying genetic mechanisms remain elusive. Here we describe...
15.
Geer M, van Geffen J, Gopalasingam P, Vogtle T, Smith C, Heising S, et al.
Blood
. 2018 Jun;
132(13):1413-1425.
PMID: 29891536
The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of ITIM...
16.
Mori J, Nagy Z, Di Nunzio G, Smith C, Geer M, Ghaithi R, et al.
Blood
. 2018 Jan;
131(10):1122-1144.
PMID: 29301754
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase...
17.
Smith C, Thomas S, Raslan Z, Patel P, Byrne M, Lordkipanidze M, et al.
Arterioscler Thromb Vasc Biol
. 2017 Mar;
37(5):823-835.
PMID: 28336561
Objective: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor that belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif-containing receptor family. It is an inhibitor of signaling via the immunoreceptor tyrosine-based...
18.
Cardo L, Thomas S, Mazharian A, Pikramenou Z, Rappoport J, Hannon M, et al.
Chembiochem
. 2015 Jun;
16(11):1680-8.
PMID: 26062886
Lifeact is a 17-residue peptide that can be employed in cell microscopy as a probe for F-actin when fused to fluorescent proteins, but therefore is not suitable for all cell...
19.
Bhavanasi D, Badolia R, Manne B, Janapati S, Dangelmaier C, Mazharian A, et al.
Thromb Haemost
. 2015 May;
114(3):558-68.
PMID: 25947062
ADP-induced thromboxane generation depends on Src family kinases (SFKs) and is enhanced with pan-protein kinase C (PKC) inhibitors, but it is not clear how these two events are linked. The...
20.
Mazharian A, Senis Y
Blood
. 2015 Jan;
125(5):747-8.
PMID: 25634614
In this issue of Blood, Bender et al provide compelling evidence that the motor protein cytoplasmic dynein provides the necessary force for microtubule sliding and proplatelet elongation from megakaryocytes.