Alexander V Yakhnin
Overview
Explore the profile of Alexander V Yakhnin including associated specialties, affiliations and a list of published articles.
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27
Citations
719
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Recent Articles
1.
Yakhnin A, Bubunenko M, Mandell Z, Lubkowska L, Husher S, Babitzke P, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2221114120.
PMID: 37276387
Transcription elongation by multi-subunit RNA polymerases (RNAPs) is regulated by auxiliary factors in all organisms. NusG/Spt5 is the only universally conserved transcription elongation factor shared by all domains of life....
2.
Jayasinghe O, Mandell Z, Yakhnin A, Kashlev M, Babitzke P
J Bacteriol
. 2022 Mar;
204(5):e0053421.
PMID: 35258320
Transcription elongation is a highly processive process that is punctuated by RNA polymerase (RNAP) pausing. Long-lived pauses can provide time for diverse regulatory events to occur, which play important roles...
3.
Mandell Z, Oshiro R, Yakhnin A, Vishwakarma R, Kashlev M, Kearns D, et al.
Elife
. 2021 Apr;
10.
PMID: 33835023
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in . While NusA was known to function as an intrinsic termination factor in , the role of NusG...
4.
Sun Z, Yakhnin A, FitzGerald P, Mclntosh C, Kashlev M
Nat Commun
. 2021 Feb;
12(1):906.
PMID: 33568644
Promoter-proximal pausing regulates eukaryotic gene expression and serves as checkpoints to assemble elongation/splicing machinery. Little is known how broadly this type of pausing regulates transcription in bacteria. We apply nascent...
5.
Yakhnin A, Kashlev M, Babitzke P
Crit Rev Biochem Mol Biol
. 2020 Oct;
55(6):716-728.
PMID: 33003953
Although transcription by RNA polymerase (RNAP) is highly processive, elongation can be transiently halted by RNAP pausing. Pausing provides time for diverse regulatory events to occur such as RNA folding...
6.
Yakhnin A, FitzGerald P, McIntosh C, Yakhnin H, KIreeva M, Turek-Herman J, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21628-21636.
PMID: 32817529
Transcription is punctuated by RNA polymerase (RNAP) pausing. These pauses provide time for diverse regulatory events that can modulate gene expression. Transcription elongation factors dramatically affect RNAP pausing in vitro,...
7.
Yakhnin H, Yakhnin A, Mouery B, Mandell Z, Karbasiafshar C, Kashlev M, et al.
mBio
. 2019 Nov;
10(6).
PMID: 31719185
Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in...
8.
Mondal S, Yakhnin A, Babitzke P
J Bacteriol
. 2017 May;
199(14).
PMID: 28507243
The operon is regulated by a transcription attenuation mechanism in which tryptophan-activated TRAP binds to the nascent transcript and blocks the formation of an antiterminator structure such that the formation...
9.
Mondal S, Yakhnin A, Sebastian A, Albert I, Babitzke P
Nat Microbiol
. 2016 Aug;
1:15007.
PMID: 27571753
Intrinsic transcription terminators consist of an RNA hairpin followed by a U-rich tract, and these signals can trigger termination without the involvement of additional factors. Although NusA is known to...
10.
Yakhnin A, Murakami K, Babitzke P
J Biol Chem
. 2016 Jan;
291(10):5299-308.
PMID: 26742846
NusG, referred to as Spt5 in archaeal and eukaryotic organisms, is the only transcription factor conserved in all three domains of life. This general transcription elongation factor binds to RNA...