Paul Babitzke
Overview
Explore the profile of Paul Babitzke including associated specialties, affiliations and a list of published articles.
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Articles
93
Citations
4012
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Recent Articles
1.
Jayasinghe O, Ritchey L, Breil T, Newman P, Yakhnin H, Babitzke P
Nucleic Acids Res
. 2024 Nov;
52(21):12945-12960.
PMID: 39494516
Transcription by RNA polymerase is punctuated by transient pausing events. Pausing provides time for RNA folding and binding of regulatory factors to the paused elongation complex. We previously identified 1600...
2.
Douds C, Babitzke P, Bevilacqua P
RNA
. 2024 Apr;
30(7):901-919.
PMID: 38670632
A key to understanding the roles of RNA in regulating gene expression is knowing their structures in vivo. One way to obtain this information is through probing the structures of...
3.
Gorelik M, Yakhnin H, Pannuri A, Walker A, Pourciau C, Czyz D, et al.
J Bacteriol
. 2024 Feb;
206(4):e0035423.
PMID: 38319100
CsrA is an RNA-binding protein that regulates processes critical for growth and survival, including central carbon metabolism, motility, biofilm formation, stress responses, and expression of virulence factors in pathogens. Transcriptomics...
4.
Pourciau C, Yakhnin H, Pannuri A, Gorelik M, Lai Y, Romeo T, et al.
mBio
. 2023 Nov;
14(6):e0258523.
PMID: 37943032
The Csr/Rsm system (carbon storage regulator or repressor of stationary phase metabolites) is a global post-transcriptional regulatory system that coordinates and responds to environmental cues and signals, facilitating the transition...
5.
Sieg J, Jolley E, Huot M, Babitzke P, Bevilacqua P
Nucleic Acids Res
. 2023 Oct;
51(20):11298-11317.
PMID: 37855684
We conducted a thermodynamic analysis of RNA stability in Eco80 artificial cytoplasm, which mimics in vivo conditions, and compared it to transcriptome-wide probing of mRNA. Eco80 contains 80% of Escherichia...
6.
Nava-Galeana J, Yakhnin H, Babitzke P, Bustamante V
Microbiol Spectr
. 2023 Jun;
11(4):e0151623.
PMID: 37358421
Enteric pathogens, such as Salmonella, have evolved to thrive in the inflamed gut. Genes located within the Salmonella pathogenicity island 1 (SPI-1) mediate the invasion of cells from the intestinal...
7.
Yakhnin A, Bubunenko M, Mandell Z, Lubkowska L, Husher S, Babitzke P, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2221114120.
PMID: 37276387
Transcription elongation by multi-subunit RNA polymerases (RNAPs) is regulated by auxiliary factors in all organisms. NusG/Spt5 is the only universally conserved transcription elongation factor shared by all domains of life....
8.
Jolley E, Yakhnin H, Tack D, Babitzke P, Bevilacqua P
RNA
. 2023 May;
29(9):1365-1378.
PMID: 37217261
RNA structure regulates bacterial gene expression by several distinct mechanisms via environmental and cellular stimuli, one of which is temperature. While some genome-wide studies have focused on heat shock treatments...
9.
Silva-Rohwer A, Held K, Yakhnin H, Babitzke P, Vadyvaloo V
J Bacteriol
. 2023 May;
205(6):e0010523.
PMID: 37191545
The plague bacterium, Yersinia pestis, forms a biofilm-mediated blockage in the flea foregut that enhances its transmission by fleabite. Biofilm formation is positively controlled by cyclic di-GMP (c-di-GMP), which is...
10.
Vishwakarma R, Qayyum M, Babitzke P, Murakami K
Proc Natl Acad Sci U S A
. 2023 Feb;
120(7):e2218516120.
PMID: 36745813
NusG is a transcription elongation factor that stimulates transcription pausing in Gram+ bacteria including by sequence-specific interaction with a conserved pause-inducing TTNTTT motif found in the non-template DNA (ntDNA) strand...