Alexander V Yakhnin
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Explore the profile of Alexander V Yakhnin including associated specialties, affiliations and a list of published articles.
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27
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719
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Recent Articles
11.
Yakhnin H, Yakhnin A, Babitzke P
Nucleic Acids Res
. 2015 Jun;
43(14):7032-43.
PMID: 26101249
Ribosomal protein genes are often controlled by autoregulatory mechanisms in which a protein encoded in the operon can either bind to newly synthesized rRNA during rapid growth or to a...
12.
Yakhnin A, Babitzke P
Curr Opin Microbiol
. 2014 Mar;
18:68-71.
PMID: 24632072
NusG/Spt5 is a transcription elongation factor that assists in DNA-templated RNA synthesis by cellular RNA polymerases (RNAP). The modular domain composition of NusG/Spt5 and the way it binds to RNAP...
13.
Yakhnin A, Baker C, Vakulskas C, Yakhnin H, Berezin I, Romeo T, et al.
Mol Microbiol
. 2013 Jan;
87(4):851-66.
PMID: 23305111
Csr is a conserved global regulatory system that controls expression of several hundred Escherichia coli genes. CsrA protein represses translation of numerous genes by binding to mRNA and inhibiting ribosome...
14.
Yakhnin A
Orig Life Evol Biosph
. 2012 Dec;
43(1):39-47.
PMID: 23242831
This model proposes that the origin of life on Earth occurred as a result of a process of alteration of the chemical composition of prebiotic macromolecules. The stability of organic...
15.
Yakhnin A, Yakhnin H, Babitzke P
Methods Mol Biol
. 2012 Jun;
905:201-11.
PMID: 22736005
The gel mobility shift assay is a powerful technique for detecting and quantifying protein-RNA interactions. While other techniques such as filter binding and isothermal titration calorimetry (ITC) are available for...
16.
Yakhnin H, Yakhnin A, Baker C, Sineva E, Berezin I, Romeo T, et al.
Mol Microbiol
. 2011 Jun;
81(3):689-704.
PMID: 21696456
CsrA of Escherichia coli is an RNA-binding protein that globally regulates gene expression by repressing translation and/or altering the stability of target transcripts. Here we explored mechanisms that control csrA...
17.
Yakhnin A, Babitzke P
Mol Microbiol
. 2010 Apr;
76(3):690-705.
PMID: 20384694
The Bacillus subtilis trpEDCFBA operon is regulated by TRAP-dependent transcription attenuation and translation repression mechanisms. Previous results showed that NusA and NusG cooperatively stimulate RNA polymerase pausing at U107 and...
18.
Yakhnin A, Yakhnin H, Babitzke P
Proc Natl Acad Sci U S A
. 2008 Oct;
105(42):16131-6.
PMID: 18852477
NusA and NusG are transcription elongation factors that bind to RNA polymerase (RNAP) after sigma subunit release. Escherichia coli NusA (NusA(Ec)) stimulates intrinsic termination and RNAP(Ec) pausing, whereas NusG(Ec) promotes...
19.
Yakhnin A
Orig Life Evol Biosph
. 2007 Sep;
37(6):523-36.
PMID: 17882534
The origin of protein synthesis is one of the major riddles of molecular biology. It was proposed a decade ago that the ribosomal RNA evolved from an earlier RNA-replisome (a...
20.
Yakhnin H, Yakhnin A, Babitzke P
J Bacteriol
. 2006 Nov;
189(3):872-9.
PMID: 17114263
Bacillus subtilis trpG encodes a glutamine amidotransferase subunit that participates in the biosynthesis of both tryptophan and folic acid. TRAP inhibits translation of trpG in response to tryptophan by binding...