Alexander Polyzos
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Explore the profile of Alexander Polyzos including associated specialties, affiliations and a list of published articles.
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31
Citations
997
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Recent Articles
1.
Breves S, Di Giammartino D, Nicholson J, Cirigliano S, Mahmood S, Lee U, et al.
bioRxiv
. 2025 Mar;
PMID: 40034649
Dysregulation of enhancer-promoter communication in the context of the three-dimensional (3D) nucleus is increasingly recognized as a potential driver of oncogenic programs. Here, we profiled the 3D enhancer-promoter networks of...
2.
Garg V, Yang Y, Nowotschin S, Setty M, Salataj E, Kuo Y, et al.
Dev Cell
. 2024 Dec;
PMID: 39729987
Two distinct lineages, pluripotent epiblast (EPI) and primitive (extra-embryonic) endoderm (PrE), arise from common inner cell mass (ICM) progenitors in mammalian embryos. To study how these sister identities are forged,...
3.
Gambi G, Boccalatte F, Rodriguez Hernaez J, Lin Z, Nadorp B, Polyzos A, et al.
Mol Cell
. 2024 Dec;
85(1):42-60.e7.
PMID: 39719705
Cancer progression involves genetic and epigenetic changes that disrupt chromatin 3D organization, affecting enhancer-promoter interactions and promoting growth. Here, we provide an integrative approach, combining chromatin conformation, accessibility, and transcription...
4.
Klagkou E, Valakos D, Foutadakis S, Polyzos A, Papadopoulou A, Vatsellas G, et al.
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684837
Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic and transcriptional...
5.
Wong E, Sahin M, Yang R, Lee U, Zhan Y, Misra R, et al.
bioRxiv
. 2024 Jun;
PMID: 38895201
Transposable elements (TEs) are abundant in the human genome, and they provide the sources for genetic and functional diversity. The regulation of TEs expression and their functional consequences in physiological...
6.
Murphy D, Salataj E, Di Giammartino D, Rodriguez-Hernaez J, Kloetgen A, Garg V, et al.
Nat Struct Mol Biol
. 2023 Dec;
31(1):125-140.
PMID: 38053013
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineages: the trophectoderm, the epiblast and the primitive endoderm. Although key signaling pathways...
7.
Murphy D, Salataj E, Di Giammartino D, Rodriguez-Hernaez J, Kloetgen A, Garg V, et al.
bioRxiv
. 2023 Aug;
PMID: 37577543
Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that give rise to three essential lineages, the trophectoderm (TE), the epiblast (EPI) and the primitive endoderm (PrE). Although...
8.
Garg V, Yang Y, Nowotschin S, Setty M, Kuo Y, Sharma R, et al.
bioRxiv
. 2023 Apr;
PMID: 37034770
Two distinct fates, pluripotent epiblast (EPI) and primitive (extra-embryonic) endoderm (PrE), arise from common progenitor cells, the inner cell mass (ICM), in mammalian embryos. To study how these sister identities...
9.
He Y, Kim I, Bian J, Polyzos A, Di Giammartino D, Zhang Y, et al.
J Thorac Oncol
. 2022 Sep;
17(12):1375-1386.
PMID: 36049655
Introduction: The pathogenesis of thymic epithelial tumors remains largely unknown. We previously identified GTF2I L424H as the most frequently recurrent mutation in thymic epithelial tumors. Nevertheless, the precise role of...
10.
Di Giammartino D, Polyzos A, Apostolou E
Methods Mol Biol
. 2022 Jul;
2532:113-141.
PMID: 35867248
The introduction of chromosome conformation capture (3C)-based technologies coupled with next-generation sequencing have significantly advanced our understanding of how the genetic material is organized within the eukaryotic nucleus. Three-dimensional (3D)...