Effie Apostolou
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Explore the profile of Effie Apostolou including associated specialties, affiliations and a list of published articles.
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58
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3293
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Recent Articles
1.
Breves S, Di Giammartino D, Nicholson J, Cirigliano S, Mahmood S, Lee U, et al.
bioRxiv
. 2025 Mar;
PMID: 40034649
Dysregulation of enhancer-promoter communication in the context of the three-dimensional (3D) nucleus is increasingly recognized as a potential driver of oncogenic programs. Here, we profiled the 3D enhancer-promoter networks of...
2.
Lee U, Laguillo-Diego A, Wong W, Ni Z, Cheng L, Li J, et al.
bioRxiv
. 2025 Mar;
PMID: 40034648
Prior studies showed that structural loops collapse upon acute cohesin depletion, while regulatory enhancer-promoter (E-P) loops largely persist, consistent with minimal transcriptional changes. However, these studies, conducted in asynchronous cells,...
3.
Gao V, Yang R, Das A, Luo R, Luo H, McNally D, et al.
Nat Commun
. 2025 Jan;
16(1):684.
PMID: 39814735
No abstract available.
4.
Shi X, Li Y, Zhou H, Hou X, Yang J, Malik V, et al.
Nat Commun
. 2024 Dec;
15(1):10803.
PMID: 39738032
Pluripotent stem cells possess a unique nuclear architecture characterized by a larger nucleus and more open chromatin, which underpins their ability to self-renew and differentiate. Here, we show that the...
5.
Garg V, Yang Y, Nowotschin S, Setty M, Salataj E, Kuo Y, et al.
Dev Cell
. 2024 Dec;
PMID: 39729987
Two distinct lineages, pluripotent epiblast (EPI) and primitive (extra-embryonic) endoderm (PrE), arise from common inner cell mass (ICM) progenitors in mammalian embryos. To study how these sister identities are forged,...
6.
Gambi G, Boccalatte F, Rodriguez Hernaez J, Lin Z, Nadorp B, Polyzos A, et al.
Mol Cell
. 2024 Dec;
85(1):42-60.e7.
PMID: 39719705
Cancer progression involves genetic and epigenetic changes that disrupt chromatin 3D organization, affecting enhancer-promoter interactions and promoting growth. Here, we provide an integrative approach, combining chromatin conformation, accessibility, and transcription...
7.
Gao V, Yang R, Das A, Luo R, Luo H, McNally D, et al.
Nat Commun
. 2024 Nov;
15(1):9432.
PMID: 39487131
Identifying cell-type-specific 3D chromatin interactions between regulatory elements can help decipher gene regulation and interpret disease-associated non-coding variants. However, achieving this resolution with current 3D genomics technologies is often infeasible...
8.
Kaplan S, Wong W, Yan J, Pulecio J, Cho H, Li Q, et al.
Cell Rep
. 2024 Aug;
43(8):114640.
PMID: 39163202
Functional enhancer annotation is critical for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants. However, unbiased enhancer discovery in disease-relevant contexts remains challenging. To identify enhancers pertinent to diabetes,...
9.
Wong E, Sahin M, Yang R, Lee U, Zhan Y, Misra R, et al.
bioRxiv
. 2024 Jun;
PMID: 38895201
Transposable elements (TEs) are abundant in the human genome, and they provide the sources for genetic and functional diversity. The regulation of TEs expression and their functional consequences in physiological...
10.
Kaplan S, Wong W, Yan J, Pulecio J, Cho H, Li Q, et al.
bioRxiv
. 2024 May;
PMID: 38746154
Functional enhancer annotation is a valuable first step for understanding tissue-specific transcriptional regulation and prioritizing disease-associated non-coding variants for investigation. However, unbiased enhancer discovery in physiologically relevant contexts remains a...