Alexander N Combes
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Explore the profile of Alexander N Combes including associated specialties, affiliations and a list of published articles.
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47
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1630
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Recent Articles
1.
Yang J, Zhuang H, Li J, Nunez-Nescolarde A, Luo N, Chen H, et al.
J Clin Invest
. 2024 Apr;
134(10).
PMID: 38625739
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis....
2.
Farahani M, Carthew J, Bhowmik S, Shard C, Nunez-Nescolarde A, Gomez G, et al.
Biointerphases
. 2022 Nov;
17(6):060801.
PMID: 36344295
The ability to create complex three-dimensional cellular models that can effectively replicate the structure and function of human organs and tissues in vitro has the potential to revolutionize medicine. Such...
3.
Raghubar A, Pham D, Tan X, Grice L, Crawford J, Lam P, et al.
Front Med (Lausanne)
. 2022 Jul;
9:873923.
PMID: 35872784
Available transcriptomes of the mammalian kidney provide limited information on the spatial interplay between different functional nephron structures due to the required dissociation of tissue with traditional transcriptome-based methodologies. A...
4.
Lu J, Azad M, Moreau J, Zhu Y, Jiang X, Tonta M, et al.
Cell Mol Life Sci
. 2022 May;
79(6):296.
PMID: 35570209
Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal...
5.
Nunez-Nescolarde A, Nikolic-Paterson D, Combes A
Am J Pathol
. 2022 Feb;
192(5):738-749.
PMID: 35181335
Kidney organoids derived from pluripotent stem cells and epithelial organoids derived from adult tissue (tubuloids) have been used to study various kidney disorders with a strong genetic component, such as...
6.
Estermann M, Mariette M, Moreau J, Combes A, Smith C
Front Cell Dev Biol
. 2021 Sep;
9:735203.
PMID: 34513849
During embryonic gonadal development, the supporting cell lineage is the first cell type to differentiate, giving rise to Sertoli cells in the testis and pre-granulosa cells in the ovary. These...
7.
Puelles V, Combes A, Bertram J
Kidney Int
. 2021 Jun;
100(4):780-786.
PMID: 34089762
For decades, measurements of kidney microanatomy using 2-dimensional sections has provided us with a detailed knowledge of kidney morphology under physiological and pathological conditions. However, the rapid development of tissue...
8.
Bagheri-Fam S, Combes A, Ling C, Wilhelm D
Hum Mol Genet
. 2020 Dec;
29(23):3781-3792.
PMID: 33305798
Heterozygous mutations in the human SOX9 gene cause the skeletal malformation syndrome campomelic dysplasia which in 75% of 46, XY individuals is associated with male-to-female sex reversal. Although studies in...
9.
Knarston I, Pachernegg S, Robevska G, Ghobrial I, Er P, Georges E, et al.
Stem Cell Reports
. 2020 Nov;
15(6):1377-1391.
PMID: 33217324
Currently an in vitro model that fully recapitulates the human embryonic gonad is lacking. Here we describe a fully defined feeder-free protocol to generate early testis-like cells with the ability...
10.
Yermalovich A, Osborne J, Sousa P, Han A, Kinney M, Chen M, et al.
Nat Commun
. 2020 Mar;
11(1):1327.
PMID: 32152305
An amendment to this paper has been published and can be accessed via a link at the top of the paper.