Luke Zappia
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Explore the profile of Luke Zappia including associated specialties, affiliations and a list of published articles.
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29
Citations
2459
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Recent Articles
1.
Zappia L, Richter S, Ramirez-Suastegui C, Kfuri-Rubens R, Vornholz L, Wang W, et al.
Nat Methods
. 2025 Mar;
PMID: 40082610
The availability of single-cell transcriptomics has allowed the construction of reference cell atlases, but their usefulness depends on the quality of dataset integration and the ability to map new samples....
2.
Jung B, Mathew J, Sheikh A, Elysee J, Duvvuri P, Fallon J, et al.
Clin Spine Surg
. 2025 Feb;
PMID: 40013700
Study Design: A retrospective Cohort Study. Objective: The aim of this study is to investigate the associations between posterior muscle health characteristics and disk geometry parameters between L1 and S1....
3.
Katz A, Song J, Duvvuri P, Shahsavarani S, Ngan A, Zappia L, et al.
Clin Spine Surg
. 2024 Nov;
PMID: 39569881
Study Design: Biomechanical analysis. Objective: To evaluate the depth of subsidence resulting from an expandable interbody cage at varying bone foam densities. Summary Of Background Data: Expandable interbody cages have...
4.
Heumos L, Ehmele P, Treis T, Upmeier Zu Belzen J, Roellin E, May L, et al.
Nat Med
. 2024 Sep;
30(11):3369-3380.
PMID: 39266748
With progressive digitalization of healthcare systems worldwide, large-scale collection of electronic health records (EHRs) has become commonplace. However, an extensible framework for comprehensive exploratory analysis that accounts for data heterogeneity...
5.
Luecken M, Gigante S, Burkhardt D, Cannoodt R, Strobl D, Markov N, et al.
Res Sq
. 2024 Apr;
PMID: 38645152
With the growing number of single-cell analysis tools, benchmarks are increasingly important to guide analysis and method development. However, a lack of standardisation and extensibility in current benchmarks limits their...
6.
Hrovatin K, Moinfar A, Zappia L, Lapuerta A, Lengerich B, Kellis M, et al.
bioRxiv
. 2023 Nov;
PMID: 37961672
Integration of single-cell RNA-sequencing (scRNA-seq) datasets has become a standard part of the analysis, with conditional variational autoencoders (cVAE) being among the most popular approaches. Increasingly, researchers are asking to...
7.
De Donno C, Hediyeh-Zadeh S, Moinfar A, Wagenstetter M, Zappia L, Lotfollahi M, et al.
Nat Methods
. 2023 Oct;
20(11):1683-1692.
PMID: 37813989
The increasing generation of population-level single-cell atlases has the potential to link sample metadata with cellular data. Constructing such references requires integration of heterogeneous cohorts with varying metadata. Here we...
8.
Hrovatin K, Bastidas-Ponce A, Bakhti M, Zappia L, Buttner M, Salinno C, et al.
Nat Metab
. 2023 Sep;
5(9):1615-1637.
PMID: 37697055
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have been generated, a consensus on pancreatic cell states in development, homeostasis and diabetes as well as the value of preclinical animal...
9.
Sikkema L, Ramirez-Suastegui C, Strobl D, Gillett T, Zappia L, Madissoon E, et al.
Nat Med
. 2023 Jun;
29(6):1563-1577.
PMID: 37291214
Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can...
10.
Ngan A, Song J, Katz A, Jung B, Zappia L, Trent S, et al.
Global Spine J
. 2023 Apr;
14(8):2270-2278.
PMID: 37116184
Study Design: Retrospective cohort study. Objectives: This study aimed to (1) evaluate for any temporal trends in the rates of VTE, deep venous thrombosis (DVT), pulmonary embolism (PE), and mortality...