Andrew H Sinclair
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Explore the profile of Andrew H Sinclair including associated specialties, affiliations and a list of published articles.
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119
Citations
2579
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Recent Articles
1.
Idris F, van den Bergen J, Robevska G, Ferreira L, Ferreira K, Kizys M, et al.
Mol Cell Endocrinol
. 2025 Jan;
598:112458.
PMID: 39788310
In mammals, male sexual development is initiated by the expression of the Sex-determining-Region-Y (SRY) gene. SRY contains a highly conserved high mobility group (HMG) box essential for DNA binding and...
2.
Kline B, Siddall N, Wijaya F, Stuart C, Orlando L, Bakhshalizadeh S, et al.
Biol Reprod
. 2024 Oct;
112(1):102-118.
PMID: 39400047
Premature ovarian insufficiency (POI) is characterized by the loss or complete absence of ovarian activity in women under the age of 40. Clinical presentation of POI varies with phenotypic severity...
3.
Touraine P, Chabbert-Buffet N, Plu-Bureau G, Duranteau L, Sinclair A, Tucker E
Nat Rev Dis Primers
. 2024 Sep;
10(1):63.
PMID: 39266563
Premature ovarian insufficiency (POI) is a cause of infertility and endocrine dysfunction in women, defined by loss of normal, predictable ovarian activity before the age of 40 years. POI is...
4.
Tan L, Young S, Sinclair A, Hunter M, Ayers K
BMC Med Genomics
. 2024 Aug;
17(1):195.
PMID: 39103808
Background: The Cut Homeobox 1 (CUX1) gene has been implicated in a number of developmental processes and has recently emerged as an important cause of developmental delay and impaired intellectual...
5.
Idris F, Sinclair A, Ayers K
Andrology
. 2024 Jul;
PMID: 39081229
: Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births...
6.
Pachernegg S, Robevska G, Ferreira L, van den Bergen J, Vlahos K, Howden S, et al.
Stem Cell Res
. 2024 Jul;
79:103494.
PMID: 39003885
The transcription factor WT1 plays a critical role in several embryonic developmental processes such as gonadogenesis, nephrogenesis, and cardiac development. We generated a homozygous (MCRIi031-A-3) WT1 knockout induced pluripotent stem...
7.
Pachernegg S, Robevska G, Ferreira L, van den Bergen J, Vlahos K, Howden S, et al.
Stem Cell Res
. 2024 Jun;
79:103484.
PMID: 38924973
The transcription factor SOX9 plays a critical role in several embryonic developmental processes such as gonadogenesis, chrondrogenesis, and cardiac development. We generated heterozygous (MCRIi031-A-1) and homozygous (MCRIi031-A-2) SOX9 knockout induced...
8.
Stenta T, Assis M, Ayers K, Tucker E, Halman A, Gook D, et al.
Clin Transl Sci
. 2024 Jun;
17(6):e13827.
PMID: 38924306
For the same age, sex, and dosage, there can be significant variation in fertility outcomes in childhood cancer survivors. Genetics may explain this variation. This study aims to: (i) review...
9.
Tucker E, Sharp M, Lokchine A, Bell K, Palmer C, Kline B, et al.
Clin Genet
. 2024 May;
106(3):321-335.
PMID: 38779778
Premature ovarian insufficiency is a common form of female infertility affecting up to 4% of women and characterised by amenorrhea with elevated gonadotropin before the age of 40. Oocytes require...
10.
Bakhshalizadeh S, Bird A, Sreenivasan R, Bell K, Robevska G, van den Bergen J, et al.
Genes (Basel)
. 2024 Mar;
15(3).
PMID: 38540391
Disruption of meiosis and DNA repair genes is associated with female fertility disorders like premature ovarian insufficiency (POI). In this study, we identified a homozygous missense variant in the gene...