Alexander J Whitworth
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Explore the profile of Alexander J Whitworth including associated specialties, affiliations and a list of published articles.
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73
Citations
10563
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Recent Articles
1.
Sanchez-Martinez A, Martinez A, Whitworth A
Methods Mol Biol
. 2024 Aug;
2845:79-93.
PMID: 39115659
Mitophagy is the degradation of mitochondria via the autophagy-lysosome system, disruption of which has been linked to multiple neurodegenerative diseases. As a flux process involving the identification, tagging, and degradation...
2.
Au W, Miller-Fleming L, Sanchez-Martinez A, Lee J, Twyning M, Prag H, et al.
Life Sci Alliance
. 2024 Jun;
7(9).
PMID: 38906677
Mitochondrial dysfunction is a common feature of amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD); however, it remains unclear whether this is a cause or consequence of the pathogenic process. Analysing multiple aspects...
3.
Martinez A, Sanchez-Martinez A, Pickering J, Twyning M, Terriente-Felix A, Chen P, et al.
Mol Neurodegener
. 2024 Jan;
19(1):12.
PMID: 38273330
Background: Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Functional analysis of genes linked...
4.
Twyning M, Tufi R, Gleeson T, Kolodziej K, Campesan S, Terriente-Felix A, et al.
Cell Rep
. 2024 Jan;
43(2):113681.
PMID: 38236772
Mitochondrial calcium (Ca) uptake augments metabolic processes and buffers cytosolic Ca levels; however, excessive mitochondrial Ca can cause cell death. Disrupted mitochondrial function and Ca homeostasis are linked to numerous...
5.
Varland S, Silva R, Kjosas I, Faustino A, Bogaert A, Billmann M, et al.
Nat Commun
. 2023 Oct;
14(1):6774.
PMID: 37891180
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic...
6.
Sanchez-Martinez A, Martinez A, Whitworth A
PLoS Biol
. 2023 Aug;
21(8):e3002244.
PMID: 37535686
Functional analyses of genes linked to heritable forms of Parkinson's disease (PD) have revealed fundamental insights into the biological processes underpinning pathogenic mechanisms. Mutations in PARK15/FBXO7 cause autosomal recessive PD...
7.
Mauri S, Bernardo G, Martinez A, Favaro M, Trevisan M, Cobraiville G, et al.
Cells
. 2023 May;
12(8).
PMID: 37190052
Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relies on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar...
8.
Castelli L, Lin Y, Sanchez-Martinez A, Gul A, Mohd Imran K, Higginbottom A, et al.
Sci Transl Med
. 2023 Mar;
15(685):eabo3823.
PMID: 36857431
Hexanucleotide repeat expansions in are the most common genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Studies have shown that the hexanucleotide expansions cause the noncanonical...
9.
Agip A, Chung I, Sanchez-Martinez A, Whitworth A, Hirst J
Elife
. 2023 Jan;
12.
PMID: 36622099
Respiratory complex I powers ATP synthesis by oxidative phosphorylation, exploiting the energy from NADH oxidation by ubiquinone to drive protons across an energy-transducing membrane. is a candidate model organism for...
10.
De Lazzari F, Agostini F, Plotegher N, Sandre M, Greggio E, Megighian A, et al.
Neurobiol Dis
. 2022 Dec;
176:105941.
PMID: 36473592
The protein DJ-1 is mutated in rare familial forms of recessive Parkinson's disease and in parkinsonism accompanied by amyotrophic lateral sclerosis symptoms and dementia. DJ-1 is considered a multitasking protein...