Alexa Burger
Overview
Explore the profile of Alexa Burger including associated specialties, affiliations and a list of published articles.
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32
Citations
1006
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Recent Articles
1.
Moran H, Nyarko O, ORourke R, Ching R, Riemslagh F, Pena B, et al.
bioRxiv
. 2024 Sep;
PMID: 39345600
The heart integrates diverse cell lineages into a functional unit, including the pericardium, a mesothelial sac that supports heart movement, homeostasis, and immune responses. However, despite its critical roles, the...
2.
Lalonde R, Wells H, Kemmler C, Nieuwenhuize S, Lerma R, Burger A, et al.
Sci Adv
. 2024 Jun;
10(23):eadn6603.
PMID: 38838146
Standard zebrafish transgenesis involves random transgene integration with resource-intensive screening. While phiC31 integrase-based / recombination has streamlined transgenesis in mice and , validated -based landing sites for universal applications are...
3.
Lalonde R, Wells H, Kemmler C, Nieuwenhuize S, Lerma R, Burger A, et al.
bioRxiv
. 2023 Dec;
PMID: 38106217
Standard methods for transgenesis in zebrafish depend on random transgene integration into the genome followed by resource-intensive screening and validation. Targeted vector integration into validated genomic loci using phiC31 integrase-based...
4.
Kemmler C, Smolikova J, Moran H, Mannion B, Knapp D, Lim F, et al.
Nat Commun
. 2023 Oct;
14(1):6594.
PMID: 37852970
The cell type-specific expression of key transcription factors is central to development and disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its...
5.
Kemmler C, Smolikova J, Moran H, Mannion B, Knapp D, Lim F, et al.
bioRxiv
. 2023 May;
PMID: 37131681
The cell type-specific expression of key transcription factors is central to development. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, and notochord formation; however, how its expression is...
6.
Kocere A, Lalonde R, Mosimann C, Burger A
Dis Model Mech
. 2023 May;
16(5).
PMID: 37125615
Syndromic birth defects are rare diseases that can present with seemingly pleiotropic comorbidities. Prime examples are rare congenital heart and cardiovascular anomalies that can be accompanied by forelimb defects, kidney...
7.
Kocere A, Chiavacci E, Soneson C, Wells H, Mendez-Acevedo K, MacGowan J, et al.
bioRxiv
. 2023 Apr;
PMID: 37090609
Defects in blood development frequently occur among syndromic congenital anomalies. Thrombocytopenia-Absent Radius (TAR) syndrome is a rare congenital condition with reduced platelets (hypomegakaryocytic thrombocytopenia) and forelimb anomalies, concurrent with more...
8.
Kemmler C, Moran H, Murray B, Scoresby A, Klem J, Eckert R, et al.
Development
. 2023 Mar;
150(8).
PMID: 36975217
Transgenesis is an essential technique for any genetic model. Tol2-based transgenesis paired with Gateway-compatible vector collections has transformed zebrafish transgenesis with an accessible modular system. Here, we establish several next-generation...
9.
Mattonet K, Riemslagh F, Guenther S, Prummel K, Kesavan G, Hans S, et al.
Sci Adv
. 2022 Aug;
8(35):eabn2082.
PMID: 36044573
Endothelial specification is a key event during embryogenesis; however, when, and how, endothelial cells separate from other lineages is poorly understood. In zebrafish, Npas4l is indispensable for endothelial specification by...
10.
Melica M, Antonelli G, Semeraro R, Angelotti M, Lugli G, Landini S, et al.
Sci Transl Med
. 2022 Aug;
14(657):eabg3277.
PMID: 35947676
Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of crescents. Little is known about the molecular...