Susan Nieuwenhuize
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Explore the profile of Susan Nieuwenhuize including associated specialties, affiliations and a list of published articles.
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9
Citations
161
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Recent Articles
1.
Lalonde R, Wells H, Kemmler C, Nieuwenhuize S, Lerma R, Burger A, et al.
Sci Adv
. 2024 Jun;
10(23):eadn6603.
PMID: 38838146
Standard zebrafish transgenesis involves random transgene integration with resource-intensive screening. While phiC31 integrase-based / recombination has streamlined transgenesis in mice and , validated -based landing sites for universal applications are...
2.
Lalonde R, Wells H, Kemmler C, Nieuwenhuize S, Lerma R, Burger A, et al.
bioRxiv
. 2023 Dec;
PMID: 38106217
Standard methods for transgenesis in zebrafish depend on random transgene integration into the genome followed by resource-intensive screening and validation. Targeted vector integration into validated genomic loci using phiC31 integrase-based...
3.
Kemmler C, Moran H, Murray B, Scoresby A, Klem J, Eckert R, et al.
Development
. 2023 Mar;
150(8).
PMID: 36975217
Transgenesis is an essential technique for any genetic model. Tol2-based transgenesis paired with Gateway-compatible vector collections has transformed zebrafish transgenesis with an accessible modular system. Here, we establish several next-generation...
4.
Lalonde R, Kemmler C, Riemslagh F, Aman A, Kresoja-Rakic J, Moran H, et al.
Dev Dyn
. 2022 May;
251(10):1754-1773.
PMID: 35582941
Background: The most-common strategy for zebrafish Cre/lox-mediated lineage labeling experiments combines ubiquitously expressed, lox-based Switch reporter transgenes with tissue-specific Cre or 4-OH-Tamoxifen-inducible CreERT2 driver lines. Although numerous Cre driver lines...
5.
Prummel K, Crowell H, Nieuwenhuize S, Brombacher E, Daetwyler S, Soneson C, et al.
Nat Commun
. 2022 Mar;
13(1):1677.
PMID: 35354817
The mesothelium lines body cavities and surrounds internal organs, widely contributing to homeostasis and regeneration. Mesothelium disruptions cause visceral anomalies and mesothelioma tumors. Nonetheless, the embryonic emergence of mesothelia remains...
6.
Prummel K, Nieuwenhuize S, Mosimann C
Development
. 2020 Jun;
147(12).
PMID: 32561665
The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite...
7.
Prummel K, Hess C, Nieuwenhuize S, Parker H, Rogers K, Kozmikova I, et al.
Nat Commun
. 2019 Aug;
10(1):3857.
PMID: 31451684
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral plate mesoderm (LPM). How the LPM initially emerges and how its downstream fates are...
8.
Felker A, Nieuwenhuize S, Dolbois A, Blazkova K, Hess C, Low L, et al.
PLoS One
. 2016 Apr;
11(4):e0152989.
PMID: 27077909
Mutant Estrogen Receptor (ERT2) ligand-binding domain fusions with Cre recombinase are a key tool for spatio-temporally controlled genetic recombination with the Cre/lox system. CreERT2 is efficiently activated in a concentration-dependent...
9.
Koorman T, Klompstra D, van der Voet M, Lemmens I, Ramalho J, Nieuwenhuize S, et al.
Nat Cell Biol
. 2016 Jan;
18(3):337-46.
PMID: 26780296
The establishment of cell polarity is an essential process for the development of multicellular organisms and the functioning of cells and tissues. Here, we combine large-scale protein interaction mapping with...