Alex Odermatt
Overview
Explore the profile of Alex Odermatt including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
204
Citations
2860
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kdzierski J, van Diest R, Allard J, Odermatt A, Smiesko M
Toxicol Lett
. 2025 Feb;
406:31-37.
PMID: 39988211
Steroid hormones regulate a wide range of physiological processes in the human body. However, exposure to xenobiotics can disrupt the hormonal balance by inhibition of enzymes involved in hormone synthesis...
2.
Blum J, Brull M, Hengstler J, Dietrich D, Gruber A, Dipalo M, et al.
ALTEX
. 2025 Jan;
42(1):167-180.
PMID: 39817434
Toxicological test methods generate raw data and provide instructions on how to use these to determine a final outcome such as a classification of test compounds as hits or non-hits....
3.
Bell L, Simonneau C, Zanini C, Kassianidou E, Zundel C, Neff R, et al.
Heliyon
. 2025 Jan;
11(1):e40813.
PMID: 39811336
Recent advancements in engineering Complex models (CIVMs) such as Blood-brain barrier (BBB) organoids offer promising platforms for preclinical drug testing. However, their application in drug development, and especially for the...
4.
Rouseti G, Fischer A, Rathfelder N, Grimes K, Waldt A, Cuttat R, et al.
Toxicology
. 2024 Dec;
511:154028.
PMID: 39643203
Drug-induced gastrointestinal toxicity is a frequent clinical adverse event that needs to be carefully monitored and managed to ensure patient compliance. While preclinical assessment of drug-induced gastrointestinal toxicity mostly relies...
5.
Kley M, Stucheli S, Ruffiner P, Temml V, Boudon S, Schuster D, et al.
Toxicology
. 2024 Nov;
509:153997.
PMID: 39532263
Parabens and UV-filters are frequently used additives in cosmetics and body care products that prolong shelf-life. They are assessed for potential endocrine disrupting properties. Antiandrogenic effects of parabens and benzophenone-type...
6.
Jager M, Gonzalez-Ruiz V, Joos F, Winter D, Boccard J, Degenhardt T, et al.
Front Pharmacol
. 2024 Aug;
15:1394846.
PMID: 39175536
The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism. Mechanisms underlying pseudohyperaldosteronism include inhibition of adrenal 11β-hydroxylase...
7.
In silico and in vitro assessment of drugs potentially causing adverse effects by inhibiting CYP17A1
Kedzierski J, Jager M, Naeem S, Odermatt A, Smiesko M
Toxicol Appl Pharmacol
. 2024 Apr;
486:116945.
PMID: 38688424
Cytochrome P450 enzymes (CYPs) play a crucial role in the metabolism and synthesis of various compound classes. While drug-metabolizing CYP enzymes are frequently investigated as anti-targets, the inhibition of CYP...
8.
Lazaridis I, Bosch A, Keller L, Low A, Tamarelle J, Moser S, et al.
Am J Physiol Endocrinol Metab
. 2024 Apr;
326(6):E819-E831.
PMID: 38630050
One-anastomosis gastric bypass (OAGB) has gained importance as a simple, safe, and effective operation to treat morbid obesity. We previously found that Roux-en-Y gastric bypass surgery with a long compared...
9.
Abegg V, Panajatovic M, Mancuso R, Allard J, Duthaler U, Odermatt A, et al.
Toxicol Lett
. 2024 Jan;
393:1-13.
PMID: 38219807
St. John's Wort preparations are used for the treatment of mild to moderate depression. They are usually well tolerated but can cause adverse reactions including liver toxicity in rare cases....
10.
Kley M, Moser S, Winter D, Odermatt A
Methods Enzymol
. 2023 Oct;
689:167-200.
PMID: 37802570
11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) converts active 11β-hydroxyglucocorticoids to their inactive 11-keto forms, fine-tuning the activation of mineralocorticoid and glucocorticoid receptors. 11β-HSD2 is expressed in mineralocorticoid target tissues such as...