Alex Odermatt
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Explore the profile of Alex Odermatt including associated specialties, affiliations and a list of published articles.
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204
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Recent Articles
11.
Kley M, Moser S, Winter D, Odermatt A
Methods Enzymol
. 2023 Oct;
689:121-165.
PMID: 37802569
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive 11-keto-glucocorticoids to their active 11β-hydroxylated forms. It also catalyzes the oxoreduction of other endogenous and exogenous substrates. The ubiquitously expressed 11β-HSD1 shows high...
12.
Kolesnyk S, Prodanchuk M, Zhminko P, Kolianchuk Y, Bubalo N, Odermatt A, et al.
Toxicol In Vitro
. 2023 Oct;
93:105706.
PMID: 37802305
Given the high attention to endocrine disrupting chemicals (EDC), there is an urgent need for the development of rapid and reliable approaches for the screening of large numbers of chemicals...
13.
Gomez C, Alimajstorovic Z, Othonos N, Winter D, White S, Lavery G, et al.
Br J Pharmacol
. 2023 Sep;
181(5):698-711.
PMID: 37740611
Background And Purpose: 11β-Hydroxysteroid dehydrogenase-1 (11β-HSD1) catalyses the oxoreduction of cortisone to cortisol, amplifying levels of active glucocorticoids. It is a pharmaceutical target in metabolic disease and cognitive impairments. 11β-HSD1...
14.
Jager M, Joos F, Winter D, Odermatt A
Curr Res Toxicol
. 2023 Aug;
5:100119.
PMID: 37637492
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are...
15.
Goodwin J, Odermatt A, Morgan R, Nixon M
Front Endocrinol (Lausanne)
. 2023 Aug;
14:1251897.
PMID: 37538788
No abstract available.
16.
Thomson P, Fragkas N, Kafu L, Aithal G, Lucena M, Terracciano L, et al.
Allergy
. 2023 Jul;
79(1):200-214.
PMID: 37515456
Background: Exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (IBU) and naproxen (NAP) is associated with idiosyncratic drug-induced liver injury (DILI). Carboxylate bioactivation into reactive metabolites (e.g., acyl glucuronides,...
17.
Jager M, Kedzierski J, Gell V, Wey T, Kollar J, Winter D, et al.
Toxicol Appl Pharmacol
. 2023 Jul;
475:116638.
PMID: 37499767
Several drugs were found after their market approval to unexpectedly inhibit adrenal 11β-hydroxylase (CYP11B1)-dependent cortisol synthesis. Known side-effects of CYP11B1 inhibition include hypertension and hypokalemia, due to a feedback activation...
18.
Kedzierski J, Allard J, Odermatt A, Smiesko M
Toxicol Lett
. 2023 Jul;
384:1-13.
PMID: 37451653
Exposure to xenobiotics can adversely affect biochemical reactions, including hepatic bile acid synthesis. Bile acids are essential for dissolving lipophilic compounds in the hydrophilic environment of the gastrointestinal tract. The...
19.
Szabo L, Cummins N, Paganetti P, Odermatt A, Papassotiropoulos A, Karch C, et al.
EMBO Rep
. 2023 Jul;
24(8):e57499.
PMID: 37401859
Abnormal tau protein impairs mitochondrial function, including transport, dynamics, and bioenergetics. Mitochondria interact with the endoplasmic reticulum (ER) via mitochondria-associated ER membranes (MAMs), which coordinate and modulate many cellular functions,...
20.
Berber M, Leng S, Wengi A, Winter D, Odermatt A, Beuschlein F, et al.
JCI Insight
. 2023 Jun;
8(14).
PMID: 37310791
The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in...