Alenka Chapron
Overview
Explore the profile of Alenka Chapron including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
241
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Recent Articles
1.
Chang S, Huang W, Chapron A, Quinones A, Wang J, Isoherranen N, et al.
Pharm Res
. 2023 Sep;
40(11):2597-2606.
PMID: 37704895
Background: Dose modification of renally secreted drugs in patients with chronic kidney disease (CKD) has relied on serum creatinine concentration as a biomarker to estimate glomerular filtration (GFR) under the...
2.
Imaoka T, Huang W, Shum S, Hailey D, Chang S, Chapron A, et al.
Sci Rep
. 2021 Nov;
11(1):21356.
PMID: 34725352
Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate...
3.
Chapron B, Chapron A, Leeder J
Br J Clin Pharmacol
. 2021 Mar;
88(10):4267-4284.
PMID: 33733546
Developmental changes that occur throughout childhood have long been known to impact drug disposition. However, pharmacokinetic studies in the paediatric population have historically been limited due to ethical concerns arising...
4.
Chapron A, Chapron B, Hailey D, Chang S, Imaoka T, Thummel K, et al.
ACS Pharmacol Transl Sci
. 2020 Jun;
3(3):496-508.
PMID: 32566915
A vascularized human proximal tubule model in a dual-channel microphysiological system (VPT-MPS) was developed, representing an advance over previous, single-cell-type kidney microphysiological systems. Human proximal tubule epithelial cells (PTECs) and...
5.
Chapron B, Chapron A, Phillips B, Okoli M, Shen D, Kelly E, et al.
ALTEX
. 2018 Jul;
35(4):504-515.
PMID: 29999169
The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that...
6.
Wong T, Wang Z, Chapron B, Suzuki M, Claw K, Gao C, et al.
Drug Metab Dispos
. 2018 Jan;
46(4):367-379.
PMID: 29343609
Metabolism of 25-hydroxyvitamin D (25OHD) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome P450-dependent hydroxylation of 25OHD has been extensively investigated,...
7.
Chang S, Weber E, Sidorenko V, Chapron A, Yeung C, Gao C, et al.
JCI Insight
. 2017 Dec;
2(22).
PMID: 29202460
Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns. Plant-derived aristolochic acids are among...
8.
Wagner D, Duan H, Chapron A, Lee R, Wang J
Xenobiotica
. 2016 Dec;
47(12):1112-1120.
PMID: 27977936
1. Beta-carbolines are indole alkaloids with a wide range of pharmacological and toxicological activities. Beta-carbolines are structurally related to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), a known substrate of organic cation transporters...
9.
Weber E, Chapron A, Chapron B, Voellinger J, Lidberg K, Yeung C, et al.
Kidney Int
. 2016 Aug;
90(3):627-37.
PMID: 27521113
The kidney proximal tubule is the primary site in the nephron for excretion of waste products through a combination of active uptake and secretory processes and is also a primary...