Danny D Shen
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Explore the profile of Danny D Shen including associated specialties, affiliations and a list of published articles.
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94
Citations
1948
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Recent Articles
1.
Perazzolo S, Shen D, Scott A, Ho R
J Pharm Sci
. 2024 Feb;
113(6):1653-1663.
PMID: 38382809
Drug-Combination Nanoparticles (DcNP) are a novel drug delivery system designed for synchronized delivery of multiple drugs in a single, long-acting, and targeted dose. Unlike depot formulations, slowly releasing drug at...
2.
Chang S, Huang W, Chapron A, Quinones A, Wang J, Isoherranen N, et al.
Pharm Res
. 2023 Sep;
40(11):2597-2606.
PMID: 37704895
Background: Dose modification of renally secreted drugs in patients with chronic kidney disease (CKD) has relied on serum creatinine concentration as a biomarker to estimate glomerular filtration (GFR) under the...
3.
Clarke J, Judson S, Tian D, Kirby T, Tanna R, Matula-Pentek A, et al.
Clin Transl Sci
. 2023 Aug;
16(10):1779-1790.
PMID: 37639334
Green tea is a popular beverage worldwide. The abundant green tea catechin (-)-epigallocatechin gallate (EGCG) is a potent in vitro inhibitor of intestinal UDP-glucuronosyltransferase (UGT) activity (K ~2 μM). Co-consuming...
4.
Wang D, Airhart S, Zhou B, Shireman L, Jiang S, Melendez Rodriguez C, et al.
JACC Basic Transl Sci
. 2023 Jan;
7(12):1183-1196.
PMID: 36644285
The mitochondrial dysfunction characteristic of heart failure (HF) is associated with changes in intracellular nicotinamide adenine dinucleotide (NAD) and NADH levels. Raising NAD levels with the NAD precursor, nicotinamide riboside...
5.
Lalovic B, Shireman L, Shen D, Cherrier M
J Clin Pharmacol
. 2022 Apr;
62(9):1177-1190.
PMID: 35394079
Little is known about how opioid responses vary by age and in the presence of alcohol consumption. This model-based pharmacokinetic (PK)-pharmacodynamic (PD) analysis quantified the impact of age and alcohol...
6.
Cherrier M, Shen D, Shireman L, Saxon A, Simpson T, Men A, et al.
Pharmacol Biochem Behav
. 2021 Nov;
211:173295.
PMID: 34742948
Background: Regular alcohol consumption is on the rise among older adults and has the potential of altering the subjective experience of pain and response to pain medications. This study examined...
7.
Perazzolo S, Shen D, Ho R
J Pharm Sci
. 2021 Oct;
111(3):825-837.
PMID: 34673094
We previously developed a mechanism-based pharmacokinetic (MBPK) model to characterize the PK of a lymphocyte-targeted, long-acting 3 HIV drug-combination nanoparticle (DcNP) formulation of lopinavir, ritonavir, and tenofovir. MBPK describes time-courses...
8.
Perazzolo S, Shireman L, Shen D, Ho R
J Pharm Sci
. 2021 Oct;
111(2):529-541.
PMID: 34673093
Drug-combination nanoparticles (DcNP) allow the formulation of multiple HIV drugs in one injectable. In nonhuman primates (NHP), all drugs in DcNP have demonstrated long-acting pharmacokinetics (PK) in the blood and...
9.
Shum S, Shen D, Isoherranen N
Drug Metab Dispos
. 2021 Aug;
49(11):1003-1015.
PMID: 34407992
Fentanyl is an opioid analgesic used to treat obstetrical pain in parturient women through epidural or intravenous route, and unfortunately can also be abused by pregnant women. Fentanyl is known...
10.
Yu J, Mu Q, Perazzolo S, Griffin J, Zhu L, McConnachie L, et al.
Pharm Res
. 2020 Sep;
37(10):197.
PMID: 32968837
Purpose: To develop drug-combination nanoparticles (DcNPs) composed of hydrophilic gemcitabine (G) and hydrophobic paclitaxel (T) and deliver both drugs to metastatic cancer cells. Methods: GT DcNPs were evaluated based on...