Brian D Chapron
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Explore the profile of Brian D Chapron including associated specialties, affiliations and a list of published articles.
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8
Citations
191
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Recent Articles
1.
Chapron B, Chapron A, Leeder J
Br J Clin Pharmacol
. 2021 Mar;
88(10):4267-4284.
PMID: 33733546
Developmental changes that occur throughout childhood have long been known to impact drug disposition. However, pharmacokinetic studies in the paediatric population have historically been limited due to ethical concerns arising...
2.
Vyhlidal C, Chapron B, Ahmed A, Singh V, Casini R, Shakhnovich V
Clin Transl Sci
. 2020 Dec;
14(2):729-736.
PMID: 33278326
Changes in absorptive capacity and first-pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing physiologically-based pharmacokinetic...
3.
Chapron B, Dinh J, Toren P, Gaedigk A, Leeder J
Drug Metab Dispos
. 2020 Aug;
48(11):1113-1120.
PMID: 32847865
Pimozide is a dopamine receptor antagonist indicated for the treatment of Tourette syndrome. Prior in vitro studies characterized dealkylation of pimozide to 1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one (DHPBI) via CYP3A4 and, to a lesser...
4.
Chapron A, Chapron B, Hailey D, Chang S, Imaoka T, Thummel K, et al.
ACS Pharmacol Transl Sci
. 2020 Jun;
3(3):496-508.
PMID: 32566915
A vascularized human proximal tubule model in a dual-channel microphysiological system (VPT-MPS) was developed, representing an advance over previous, single-cell-type kidney microphysiological systems. Human proximal tubule epithelial cells (PTECs) and...
5.
Chapron B, Chapron A, Phillips B, Okoli M, Shen D, Kelly E, et al.
ALTEX
. 2018 Jul;
35(4):504-515.
PMID: 29999169
The role of megalin in the regulation of renal vitamin D homeostasis has previously been evaluated in megalin-knockout mice and rat proximal tubule epithelial cells. We revisited these hypotheses that...
6.
Wong T, Wang Z, Chapron B, Suzuki M, Claw K, Gao C, et al.
Drug Metab Dispos
. 2018 Jan;
46(4):367-379.
PMID: 29343609
Metabolism of 25-hydroxyvitamin D (25OHD) plays a central role in regulating the biologic effects of vitamin D in the body. Although cytochrome P450-dependent hydroxylation of 25OHD has been extensively investigated,...
7.
Weber E, Chapron A, Chapron B, Voellinger J, Lidberg K, Yeung C, et al.
Kidney Int
. 2016 Aug;
90(3):627-37.
PMID: 27521113
The kidney proximal tubule is the primary site in the nephron for excretion of waste products through a combination of active uptake and secretory processes and is also a primary...
8.
Yamaura Y, Chapron B, Wang Z, Himmelfarb J, Thummel K
Drug Metab Dispos
. 2015 Dec;
44(3):329-35.
PMID: 26700954
To further the development of a model for simultaneously assessing intestinal absorption and first-pass metabolism in vitro, Caco-2, LS180, T84, and fetal human small intestinal epithelial cells (fSIECs) were cultured...