Alastair W Poole
Overview
Explore the profile of Alastair W Poole including associated specialties, affiliations and a list of published articles.
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96
Citations
2113
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Recent Articles
1.
Protty M, Tyrrell V, Hajeyah A, Morgan B, Costa D, Li Y, et al.
J Lipid Res
. 2024 Dec;
66(1):100727.
PMID: 39674322
Enzymatically oxygenated phospholipids (eoxPL) from lipoxygenases (LOX) or cyclooxygenase (COX) are prothrombotic. Their generation in arterial disease, and their modulation by cardiovascular therapies is unknown. Furthermore, the Lands cycle acyl-transferases...
2.
Tsuji C, Bradshaw M, Allen M, Jackson M, Mantell J, Borucu U, et al.
Nat Commun
. 2024 Nov;
15(1):10328.
PMID: 39609448
No abstract available.
3.
Li Y, Furniss J, Vautrinot J, Williams C, Walsh T, Brill A, et al.
J Thromb Haemost
. 2024 Oct;
23(1):254-261.
PMID: 39454881
Background: Deep vein thrombosis is a major cause of morbidity and mortality globally. While its pathophysiology is complex, increasing evidence suggests a more prominent role for platelets than previously suspected....
4.
Furniss J, Tarassova N, Poole A
Blood
. 2024 Oct;
144(22):2283-2294.
PMID: 39357055
Platelets play crucial roles in hemostasis, thrombosis, and immunity, but our understanding of their complex biogenesis (thrombopoiesis) is currently incomplete. Deeper insight into the mechanisms of platelet biogenesis inside and...
5.
Tsuji C, Bradshaw M, Allen M, Jackson M, Mantell J, Borucu U, et al.
Nat Commun
. 2024 Jul;
15(1):5967.
PMID: 39013865
Crosstalk between the actin and microtubule cytoskeletons is important for many cellular processes. Recent studies have shown that microtubules and F-actin can assemble to form a composite structure where F-actin...
6.
7.
Agbani E, Young D, Chen S, Smith S, Lee A, Poole A, et al.
Commun Med (Lond)
. 2023 Sep;
3(1):125.
PMID: 37735203
Background: The Montreal platelet syndrome kindred (MPS) with VWF p.V1316M mutation (2B-VWDMPS) is an extremely rare disorder. It has been associated with macrothrombocytopenia, spontaneous platelet clumping, mucocutaneous, and other bleeding,...
8.
Zhao X, Alibhai D, Walsh T, Tarassova N, Englert M, Birol S, et al.
Nat Commun
. 2023 Jul;
14(1):4026.
PMID: 37419900
Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear. Outside the body, however, our ability...
9.
Agbani E, Chow L, Nicholas J, Skeith L, Schneider P, Gregory A, et al.
J Thromb Haemost
. 2023 Mar;
21(7):1903-1919.
PMID: 36963633
Background: Preeclampsia (PE) is a hypertensive disorder during pregnancy that results in significant adverse maternal and neonatal outcomes. Platelet activation is present in PE and contributes to the thrombo-hemorrhagic states...
10.
Goudswaard L, Williams C, Khalil J, Burley K, Hamilton F, Arnold D, et al.
J Thromb Haemost
. 2023 Jan;
21(5):1307-1321.
PMID: 36716966
Background: Patients with COVID-19 are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality. Objectives: To characterize the mechanism of altered...