Stuart J Mundell
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Explore the profile of Stuart J Mundell including associated specialties, affiliations and a list of published articles.
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42
Citations
772
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Recent Articles
1.
Nock S, Hutchinson J, Blanco-Lopez M, Naseem K, Jones S, Mundell S, et al.
J Thromb Haemost
. 2025 Jan;
23(1):293-305.
PMID: 39798965
Background: The thromboxane A2 receptor (TPαR) plays an important role in the amplification of platelet responses during thrombosis. Receptor activity is regulated by internalization and receptor desensitization. The mechanism by...
2.
Allen M, Hutchinson J, Keith M, Mallah S, Corey R, Trory J, et al.
Br J Pharmacol
. 2024 Jun;
181(19):3685-3699.
PMID: 38840293
Background And Purpose: Thromboxane A (TXA) is a prostanoid produced during platelet activaton, important in enhancing platelet reactivity by activation of TP receptors. However, due to the short half-life, studying...
3.
Khalil J, Dimofte T, Roberts T, Keith M, Amaradasa K, Hindle M, et al.
Br J Pharmacol
. 2023 Aug;
181(1):21-35.
PMID: 37530222
Background And Purpose: Ticagrelor is labelled as a reversible, direct-acting platelet P2Y receptor (P2Y R) antagonist that is indicated clinically for the prevention of thrombotic events in patients with acute...
4.
Goudswaard L, Williams C, Khalil J, Burley K, Hamilton F, Arnold D, et al.
J Thromb Haemost
. 2023 Jan;
21(5):1307-1321.
PMID: 36716966
Background: Patients with COVID-19 are at increased risk of thrombosis, which is associated with altered platelet function and coagulopathy, contributing to excess mortality. Objectives: To characterize the mechanism of altered...
5.
Hers I, Mundell S
J Thromb Haemost
. 2021 Apr;
19(8):1848-1851.
PMID: 33908157
No abstract available.
6.
Zhao X, Alibhai D, Sun T, Khalil J, Hutchinson J, Olzak K, et al.
Blood Adv
. 2021 Apr;
5(7):1884-1898.
PMID: 33792632
The reactivity of platelets, which play a key role in the pathogenesis of atherothrombosis, is tightly regulated. The integral membrane protein tetherin/bone marrow stromal antigen-2 (BST-2) regulates membrane organization, altering...
7.
Johnson T, Baos S, Collett L, Hutchinson J, Nkau M, Molina M, et al.
J Am Heart Assoc
. 2020 Dec;
9(24):e016495.
PMID: 33305660
Background To assess differences in platelet inhibition during ticagrelor monotherapy (TIC) or dual therapy with ticagrelor and aspirin (TIC+ASP) in patients after percutaneous coronary intervention using a comprehensive panel of...
8.
Unsworth A, Bye A, Sage T, Gaspar R, Eaton N, Drew C, et al.
Haematologica
. 2020 May;
106(7):1968-1978.
PMID: 32467143
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We...
9.
Hutchinson J, Zhao X, Hill R, Mundell S
Platelets
. 2019 Nov;
31(5):641-645.
PMID: 31684789
The principal demonstrated role of the nonvisual arrestins is to limit G protein-coupled receptor (GPCR) signaling. Nonetheless, a direct demonstration of this fundamental ability in platelets remains lacking, despite the...
10.
Cunningham M, Aungraheeta R, Mundell S
Mol Cell Endocrinol
. 2017 Feb;
449:74-81.
PMID: 28212842
Genetic variations in G protein-coupled receptor (GPCR) genes can disrupt receptor function in a wide variety of human genetic diseases, including platelet bleeding disorders. Platelets are critical for haemostasis with...