Alastair R Hawkins
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Explore the profile of Alastair R Hawkins including associated specialties, affiliations and a list of published articles.
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Citations
618
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Recent Articles
11.
Rogowski A, Briggs J, Mortimer J, Tryfona T, Terrapon N, Lowe E, et al.
Nat Commun
. 2015 Jun;
6:7481.
PMID: 26112186
The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of...
12.
Tizon L, Maneiro M, Peon A, Otero J, Lence E, Poza S, et al.
Org Biomol Chem
. 2014 Nov;
13(3):706-16.
PMID: 25370445
The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid pathway, is investigated by structural, biochemical and computational studies. Two epoxides, which are mimetics of...
13.
Maneiro M, Peon A, Lence E, Otero J, van Raaij M, Thompson P, et al.
Biochem J
. 2014 Jun;
462(3):415-24.
PMID: 24957267
Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme active site are reported in the present...
14.
Blanco B, Sedes A, Peon A, Otero J, van Raaij M, Thompson P, et al.
J Med Chem
. 2014 Apr;
57(8):3494-510.
PMID: 24689821
Structural and computational studies to explore the WAT1 binding pocket in the structure-based design of inhibitors against the type II dehydroquinase (DHQ2) enzyme are reported. The crystal structures of DHQ2...
15.
Coderch C, Lence E, Peon A, Lamb H, Hawkins A, Gago F, et al.
Biochem J
. 2014 Jan;
458(3):547-57.
PMID: 24392963
DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target...
16.
Blanco B, Prado V, Lence E, Otero J, Garcia-Doval C, van Raaij M, et al.
J Am Chem Soc
. 2013 Jul;
135(33):12366-76.
PMID: 23889343
Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive target for the development of...
17.
Lence E, Tizon L, Otero J, Peon A, Prazeres V, Llamas-Saiz A, et al.
ACS Chem Biol
. 2012 Dec;
8(3):568-77.
PMID: 23198883
The structural changes caused by the substitution of the aromatic moiety in (2S)-2-benzyl-3-dehydroquinic acids and its epimers in C2 by electron-withdrawing or electron-donating groups in type II dehydroquinase enzyme from...
18.
Varsaki A, Lamb H, Eleftheriadou O, Vandera E, Thompson P, Moncalian G, et al.
FEBS Lett
. 2012 Mar;
586(6):675-9.
PMID: 22449962
MbeA and MbeC are two key proteins in plasmid ColE1 conjugal mobilization. Isothermal titration calorimetry was used to detect and quantify an interaction between MbeA and MbeC. As a result...
19.
Blanco B, Sedes A, Peon A, Lamb H, Hawkins A, Castedo L, et al.
Org Biomol Chem
. 2012 Mar;
10(18):3662-76.
PMID: 22447158
Several 3-alkylaryl mimics of the enol intermediate in the reaction catalyzed by type II dehydroquinase were synthesized to investigate the effect on the inhibition potency of replacing the oxygen atom...
20.
Tizon L, Otero J, Prazeres V, Llamas-Saiz A, Fox G, van Raaij M, et al.
J Med Chem
. 2011 Jul;
54(17):6063-84.
PMID: 21780742
The synthesis of high-affinity reversible competitive inhibitors of Mycobacterium tuberculosis type II dehydroquinase, an essential enzyme in Mycobacterium tuberculosis bacteria, is reported. The inhibitors reported here are mimics of the...