Michael Lockyer
Overview
Explore the profile of Michael Lockyer including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
288
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Recent Articles
1.
Stamp A, Owen P, El Omari K, Lockyer M, Lamb H, Charles I, et al.
Proteins
. 2011 May;
79(7):2352-7.
PMID: 21560168
No abstract available.
2.
Stamp A, Owen P, El Omari K, Nichols C, Lockyer M, Lamb H, et al.
Protein Sci
. 2010 Jul;
19(10):1897-905.
PMID: 20669241
YcbL has been annotated as either a metallo-β-lactamase or glyoxalase II (GLX2), both members of the zinc metallohydrolase superfamily, that contains many enzymes with a diverse range of activities. Here,...
3.
Chaudhuri R, Allen A, Owen P, Shalom G, Stone K, Harrison M, et al.
BMC Genomics
. 2009 Jul;
10:291.
PMID: 19570206
Background: In recent years there has been an increasing problem with Staphylococcus aureus strains that are resistant to treatment with existing antibiotics. An important starting point for the development of...
4.
Lamb H, Thompson P, Elliott C, Charles I, Richards J, Lockyer M, et al.
Protein Sci
. 2007 Oct;
16(11):2391-402.
PMID: 17905831
The S. typhimurium genome encodes proteins, designated EngA and YhbZ, which have a high sequence identity with the GTPases EngA/Der and ObgE/CgtAE of Escherichia coli. The wild-type activity of the...
5.
El Omari K, Dhaliwal B, Lockyer M, Charles I, Hawkins A, Stammers D
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Oct;
62(Pt 10):949-53.
PMID: 17012781
Nucleotide monophosphate kinases (NMPKs) are potential antimicrobial drug targets owing to their role in supplying DNA and RNA precursors. The present work reports the crystal structure of Staphylococcus aureus guanylate...
6.
Kotaka M, Ren J, Lockyer M, Hawkins A, Stammers D
J Biol Chem
. 2006 Aug;
281(42):31544-52.
PMID: 16905770
Aspartokinase III (AKIII) from Escherichia coli catalyzes an initial commitment step of the aspartate pathway, giving biosynthesis of certain amino acids including lysine. We report crystal structures of AKIII in...
7.
Dhaliwal B, Ren J, Lockyer M, Charles I, Hawkins A, Stammers D
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Aug;
62(Pt 8):710-5.
PMID: 16880539
The crystal structure of Staphylococcus aureus cytidine monophosphate kinase (CMK) in complex with cytidine 5'-monophosphate (CMP) has been determined at 2.3 angstroms resolution. The active site reveals novel features when...
8.
Kotaka M, Dhaliwal B, Ren J, Nichols C, Angell R, Lockyer M, et al.
Protein Sci
. 2006 Mar;
15(4):774-84.
PMID: 16522804
Methicillin-resistant Staphylococcus aureus (MRSA) poses a major threat to human health, particularly through hospital acquired infection. The spread of MRSA means that novel targets are required to develop potential inhibitors...
9.
Ren J, Kotaka M, Lockyer M, Lamb H, Hawkins A, Stammers D
J Biol Chem
. 2005 Aug;
280(44):36912-9.
PMID: 16115872
GTP cyclohydrolase II converts GTP to 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and pyrophosphate, the first step in riboflavin biosynthesis. The essential role of riboflavin in metabolism and the absence of GTP cyclohydrolase...
10.
Dhaliwal B, Nichols C, Ren J, Lockyer M, Charles I, Hawkins A, et al.
FEBS Lett
. 2004 Sep;
574(1-3):49-54.
PMID: 15358538
The X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase (SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2.15 A. The binding of shikimate...