Alasdair C Steven
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Explore the profile of Alasdair C Steven including associated specialties, affiliations and a list of published articles.
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167
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7084
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Recent Articles
1.
Eren E, Wang B, Winkler D, Watts N, Steven A, Wingfield P
Structure
. 2022 Feb;
30(4):551-563.e4.
PMID: 35150605
Encapsulins are bacterial organelle-like cages involved in various aspects of metabolism, especially protection from oxidative stress. They can serve as vehicles for a wide range of medical applications. Encapsulin shell...
2.
Dixit U, Bhutoria S, Wu X, Qiu L, Spira M, Mathew S, et al.
Nat Commun
. 2021 May;
12(1):2743.
PMID: 33980829
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal...
3.
Buch M, Newcomb W, Winkler D, Steven A, Heymann J
mBio
. 2021 Mar;
12(2).
PMID: 33727359
Herpes simplex virus 1 (HSV-1) requires seven proteins to package its genome through a vertex in its capsid, one of which is the portal protein, pUL6. The portal protein is...
4.
Wu W, Cheng N, Black L, Dietz H, Steven A
Viruses
. 2020 Nov;
12(11).
PMID: 33182609
The virions of tailed bacteriophages and the evolutionarily related herpesviruses contain, in addition to highly condensed DNA, substantial quantities of internal proteins. These proteins ("ejection proteins") have roles in scaffolding,...
5.
Heymann J, Wang B, Newcomb W, Wu W, Winkler D, Cheng N, et al.
Viruses
. 2020 Aug;
12(9).
PMID: 32825132
"Giant" phages have genomes of >200 kbp, confined in correspondingly large capsids whose assembly and maturation are still poorly understood. Nevertheless, the first assembly product is likely to be, as...
6.
Wu W, Watts N, Cheng N, Huang R, Steven A, Wingfield P
PLoS Comput Biol
. 2020 Apr;
16(4):e1007782.
PMID: 32310951
Hepatitis B virus (HBV) is a leading cause of liver disease. The capsid is an essential component of the virion and it is therefore of interest how it assembles and...
7.
Bayfield O, Steven A, Antson A
Elife
. 2020 Apr;
9.
PMID: 32286226
The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA...
8.
Watts N, Palmer I, Eren E, Steven A, Wingfield P
FEBS Lett
. 2019 Dec;
594(6):1052-1061.
PMID: 31792961
The hepatitis B virus e antigen, an alternative transcript of the core gene, is a secreted protein that maintains viral persistence. The physiological form has extended C termini relative to...
9.
Bayfield O, Klimuk E, Winkler D, Hesketh E, Chechik M, Cheng N, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(9):3556-3561.
PMID: 30737287
Double-stranded DNA viruses, including bacteriophages and herpesviruses, package their genomes into preformed capsids, using ATP-driven motors. Seeking to advance structural and mechanistic understanding, we established in vitro packaging for a...
10.
Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina
Heymann J, Vijayasarathy C, Huang R, Dearborn A, Sieving P, Steven A
J Cell Biol
. 2019 Jan;
218(3):1027-1038.
PMID: 30630865
Mutations in the retinal protein retinoschisin (RS1) cause progressive loss of vision in young males, a form of macular degeneration called X-linked retinoschisis (XLRS). We previously solved the structure of...