Paul T Wingfield
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Explore the profile of Paul T Wingfield including associated specialties, affiliations and a list of published articles.
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75
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2280
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Recent Articles
1.
Montecinos F, Eren E, Watts N, Sackett D, Wingfield P
J Biol Chem
. 2024 Dec;
301(2):108132.
PMID: 39725029
Microtubule (MT) function plasticity originates from its composition of α- and β-tubulin isotypes and the posttranslational modifications of both subunits. Aspects such as MT assembly dynamics, structure, and anticancer drug...
2.
Degenhardt M, Degenhardt H, Bhandari Y, Lee Y, Ding J, Yu P, et al.
Nature
. 2024 Dec;
637(8048):1234-1243.
PMID: 39695231
Much of the human genome is transcribed into RNAs, many of which contain structural elements that are important for their function. Such RNA molecules-including those that are structured and well-folded-are...
3.
Eren E, Watts N, Montecinos F, Wingfield P
Biomolecules
. 2024 Jun;
14(6).
PMID: 38927029
Encapsulins are self-assembling nano-compartments that naturally occur in bacteria and archaea. These nano-compartments encapsulate cargo proteins that bind to the shell's interior through specific recognition sequences and perform various metabolic...
4.
Eren E, Watts N, Conway J, Wingfield P
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2400426121.
PMID: 38748579
Encapsulins are protein nanocompartments that regulate cellular metabolism in several bacteria and archaea. encapsulins protect the bacterial cells against oxidative stress by sequestering cytosolic iron. These encapsulins are formed by...
5.
Eren E, Watts N, Randazzo D, Palmer I, Sackett D, Wingfield P
Structure
. 2023 Aug;
31(10):1233-1246.e5.
PMID: 37572662
HIV-1 Rev is an essential regulatory protein that transports unspliced and partially spliced viral mRNAs from the nucleus to the cytoplasm for the expression of viral structural proteins. During its...
6.
Watts N, Eren E, Palmer I, Huang P, Huang P, Shoemaker R, et al.
PLoS One
. 2023 Jun;
18(6):e0286370.
PMID: 37384752
The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 and Momordin which are derived from...
7.
Shoemaker R, Panettieri Jr R, Libutti S, Hochster H, Watts N, Wingfield P, et al.
PLoS One
. 2022 Jul;
17(7):e0271066.
PMID: 35816490
As ACE2 is the critical SARS-CoV-2 receptor, we hypothesized that aerosol administration of clinical grade soluble human recombinant ACE2 (APN01) will neutralize SARS-CoV-2 in the airways, limit spread of infection...
8.
Eren E, Wang B, Winkler D, Watts N, Steven A, Wingfield P
Structure
. 2022 Feb;
30(4):551-563.e4.
PMID: 35150605
Encapsulins are bacterial organelle-like cages involved in various aspects of metabolism, especially protection from oxidative stress. They can serve as vehicles for a wide range of medical applications. Encapsulin shell...
9.
Shoemaker R, Panettieri Jr R, Libutti S, Hochster H, Watts N, Wingfield P, et al.
bioRxiv
. 2021 Sep;
PMID: 34545364
To develop a universal strategy to block SARS-CoV-2 cellular entry and infection represents a central aim for effective COVID-19 therapy. The growing impact of emerging variants of concern increases the...
10.
Eren E, Watts N, Sackett D, Wingfield P
J Biol Chem
. 2021 Aug;
297(4):101138.
PMID: 34461087
Cryptophycin-52 (Cp-52) is potentially the most potent anticancer drug known, with IC values in the low picomolar range, but its binding site on tubulin and mechanism of action are unknown....