Alasdair C Steven
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Explore the profile of Alasdair C Steven including associated specialties, affiliations and a list of published articles.
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167
Citations
7084
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Recent Articles
11.
Amaro R, Ieong P, Huber G, Dommer A, Steven A, Bush R, et al.
ACS Cent Sci
. 2018 Dec;
4(11):1570-1577.
PMID: 30555910
Studies of pathogen-host specificity, virulence, and transmissibility are critical for basic research as well as for assessing the pandemic potential of emerging infectious diseases. This is especially true for viruses...
12.
Weintraub S, Mohd Redzuan N, Barton M, Md Amin N, Desmond M, Adams L, et al.
J Virol
. 2018 Dec;
93(5).
PMID: 30541839
The 240-kb phage SPN3US genome encodes 264 gene products, many of which are functionally uncharacterized. We have previously used mass spectrometry to define the proteomes of wild-type and mutant forms...
13.
Novikova M, Adams L, Fontana J, Gres A, Balasubramaniam M, Winkler D, et al.
mBio
. 2018 Oct;
9(5).
PMID: 30327442
Late in the HIV-1 replication cycle, the viral structural protein Gag is targeted to virus assembly sites at the plasma membrane of infected cells. The capsid (CA) domain of Gag...
14.
Eren E, Watts N, Dearborn A, Palmer I, Kaufman J, Steven A, et al.
Structure
. 2018 Aug;
26(10):1314-1326.e4.
PMID: 30100358
Hepatitis B virus (HBV) is the leading cause of liver disease worldwide. While an adequate vaccine is available, current treatment options are limited, not highly effective, and associated with adverse...
15.
Mata C, Mertens J, Fontana J, Luque D, Allende-Ballestero C, Reguera D, et al.
J Virol
. 2018 Jul;
92(19).
PMID: 30021893
Infectious bursal disease virus (IBDV), a nonenveloped, double-stranded RNA (dsRNA) virus with a T=13 icosahedral capsid, has a virion assembly strategy that initiates with a precursor particle based on an...
16.
Dearborn A, Eren E, Watts N, Palmer I, Kaufman J, Steven A, et al.
Structure
. 2018 Jul;
26(9):1187-1195.e4.
PMID: 30017564
HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNAs for production of viral genomes and structural proteins. Rev assembles on a 351-nt Rev response element (RRE)...
17.
Watts N, Eren E, Zhuang X, Wang Y, Steven A, Wingfield P
J Struct Biol
. 2018 Apr;
203(2):102-108.
PMID: 29605570
HIV-1 Rev mediates the nuclear export of unspliced and partially-spliced viral transcripts for the production of progeny genomes and structural proteins. In this process, four (or more) copies of Rev...
18.
19.
Zhuang X, Watts N, Palmer I, Kaufman J, Dearborn A, Trenbeath J, et al.
J Biol Chem
. 2017 Aug;
292(40):16760-16772.
PMID: 28842495
Hepatitis B virus (HBV) infection afflicts millions worldwide, causing cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease severity, is a soluble variant of the viral capsid...
20.
Newcomb W, Fontana J, Winkler D, Cheng N, Heymann J, Steven A
mBio
. 2017 Jun;
8(3).
PMID: 28611252
Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm. First, the capsid buds through...