Alan C Rigby
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Explore the profile of Alan C Rigby including associated specialties, affiliations and a list of published articles.
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44
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1150
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Recent Articles
1.
Thomson C, Aicher T, Cheng W, Du H, Dudgeon C, Li A, et al.
J Med Chem
. 2024 Mar;
67(7):5259-5271.
PMID: 38530741
A series of activators of GCN2 (general control nonderepressible 2) kinase have been developed, leading to HC-7366, which has entered the clinic as an antitumor therapy. Optimization resulted in improved...
2.
Stokes M, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, et al.
Clin Cancer Res
. 2023 Sep;
29(23):4870-4882.
PMID: 37733811
Purpose: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation strategy. Here, we tested the hypothesis...
3.
Stokes M, Surman M, Calvo V, Surguladze D, Li A, Gasparek J, et al.
Pharmaceutics
. 2022 Oct;
14(10).
PMID: 36297668
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and...
4.
Calvo V, Surguladze D, Li A, Surman M, Malibhatla S, Bandaru M, et al.
Bioorg Med Chem Lett
. 2021 Apr;
43:128058.
PMID: 33895276
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of the three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) that regulates protein synthesis, alleviates...
5.
Sharma A, Lee S, Zhou M, Rigby A, Townson S
Biomol NMR Assign
. 2019 Feb;
13(1):227-231.
PMID: 30798456
K-Ras exists in two distinct structural conformations specific to binding of GDP and GTP nucleotides. The cycling between an inactive, GDP-bound state and an active, GTP-bound state is regulated by...
6.
Sharma A, Lee S, Rigby A, Townson S
Biomol NMR Assign
. 2018 May;
12(2):269-272.
PMID: 29721757
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by...
7.
Sharma A, Krieger T, Rigby A, Zelikovic I, Alper S
Biochem Biophys Rep
. 2017 Sep;
8:184-191.
PMID: 28955955
Mutations in the human SLC26A4/Pendrin polypeptide (hPDS) cause Pendred Syndrome /DFNB4, syndromic deafness with enlargement of the vestibular aqueduct and low-penetrance goiter. Here we present data on cloning, protein overexpression...
8.
Khedkar S, Samad M, Choudhury S, Lee J, Zhang D, Thadhani R, et al.
Sci Rep
. 2017 Aug;
7(1):8427.
PMID: 28814738
Vitamin D regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect. Using a virtual screening platform to search novel chemical probes that activate the vitamin...
9.
Bezzerides V, Zhang A, Xiao L, Simonson B, Khedkar S, Baba S, et al.
Sci Rep
. 2017 Mar;
7(1):346.
PMID: 28336914
Alterations in sodium flux (I) play an important role in the pathogenesis of cardiac arrhythmias and may also contribute to the development of cardiomyopathies. We have recently demonstrated a critical...
10.
Sharma A, Birrane G, Anklin C, Rigby A, Alper S
J Biol Chem
. 2017 Mar;
292(17):7052-7065.
PMID: 28280239
Nitrovasodilators relax vascular smooth-muscle cells in part by modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine zipper (LZ) domain of the myosin light-chain phosphatase component, myosin-binding...