Ajit G Thomas
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Explore the profile of Ajit G Thomas including associated specialties, affiliations and a list of published articles.
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74
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2911
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Recent Articles
1.
Huang M, Stremlau M, Zavras J, Zivko C, Thomas A, Pietri P, et al.
Adv Pharmacol
. 2025 Feb;
102:65-101.
PMID: 39929585
Neutral sphingomyelinase 2 (nSMase2), encoded by the SMPD3 gene, is a pivotal enzyme in sphingolipid metabolism, hydrolyzing sphingomyelin to produce ceramide, a bioactive lipid involved in apoptosis, inflammation, membrane structure,...
2.
Su Y, Huang M, Thomas A, Maragakis J, Huizar K, Zheng Y, et al.
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000003
Peripheral nerve injuries (PNIs) represent a significant clinical challenge, particularly in elderly populations where axonal remyelination and regeneration are impaired. Developing therapies to enhance these processes is crucial for improving...
3.
Tallon C, Bell B, Malvankar M, Deme P, Nogueras-Ortiz C, Eren E, et al.
Transl Neurodegener
. 2023 Dec;
12(1):56.
PMID: 38049923
Background: Cognitive decline in Alzheimer's disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered...
4.
Huang M, Tallon C, Zhu X, Huizar K, Picciolini S, Thomas A, et al.
Pharmaceutics
. 2023 Sep;
15(9).
PMID: 37765332
The progression of Alzheimer's disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex. Neutral sphingomyelinase2 (nSMase2) is critical in the...
5.
Peters D, Norris L, Tenora L, Snajdr I, Ponti A, Zhu X, et al.
Sci Transl Med
. 2023 Aug;
15(708):eabn7491.
PMID: 37556558
There is an urgent need to develop therapeutics for inflammatory bowel disease (IBD) because up to 40% of patients with moderate-to-severe IBD are not adequately controlled with existing drugs. Glutamate...
6.
Novotna K, Thomas A, Stepanek O, Murphy B, Hin N, Skacel J, et al.
Eur J Med Chem
. 2023 Aug;
259:115674.
PMID: 37536209
Neutral sphingomyelinase 2 (nSMase2) has gained increasing attention as a therapeutic target to regulate ceramide production in various disease conditions. Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)-pyrrolidin-3-yl)carbamate (PDDC) is a submicromolar nSMase2 inhibitor and has...
7.
Tallon C, Bell B, Malvankar M, Deme P, Nogueras-Ortiz C, Eren E, et al.
Res Sq
. 2023 Jul;
PMID: 37502930
Background: Cognitive decline in Alzheimer's disease (AD) is associated with prion-like tau propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EV). EV biogenesis is triggered by...
8.
Lee K, Thompson E, Gharaie S, Patel C, Kurzhagen J, Pierorazio P, et al.
JCI Insight
. 2023 May;
8(12).
PMID: 37166984
T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is unknown in AKI. We...
9.
Zhang F, Zhang Z, Alt J, Kambhampati S, Sharma A, Singh S, et al.
J Control Release
. 2023 Apr;
358:27-42.
PMID: 37054778
Glutamate carboxypeptidase II (GCPII), localized on the surface of astrocytes and activated microglia, regulates extracellular glutamate concentration in the central nervous system (CNS). We have previously shown that GCPII is...
10.
Rais R, Lemberg K, Tenora L, Arwood M, Pal A, Alt J, et al.
Sci Adv
. 2022 Nov;
8(46):eabq5925.
PMID: 36383674
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8 T cells. DON showed promising efficacy in clinical trials; however,...