Ajaybabu V Pobbati
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Explore the profile of Ajaybabu V Pobbati including associated specialties, affiliations and a list of published articles.
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29
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1396
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Recent Articles
1.
Pobbati A, Burtscher A, Rajaram Siva N, Hallett A, Romigh T, Che K, et al.
Clin Cancer Res
. 2024 Jul;
30(18):4179-4189.
PMID: 39052240
Purpose: There are no effective treatment options for patients with aggressive epithelioid hemangioendothelioma (EHE) driven by the TAZ-CAMTA1 (TC) fusion gene. Here, we aimed to understand the regulation of TC...
2.
Zhao B, Pobbati A, Rubin B, Stauffer S
Pharmaceuticals (Basel)
. 2023 Apr;
16(4).
PMID: 37111340
The Hippo signaling pathway is a highly conserved pathway that plays important roles in the regulation of cell proliferation and apoptosis. Transcription factors TEAD1-4 and transcriptional coregulators YAP/TAZ are the...
3.
Pobbati A, Kumar R, Rubin B, Hong W
Trends Biochem Sci
. 2023 Jan;
48(5):450-462.
PMID: 36709077
The Hippo signaling pathway inhibits the activity of the oncogenic YAP (Yes-associated protein)/TAZ (transcriptional co-activator with PDZ-binding motif)-TEAD (TEA/ATTS domain) transcriptional complex. In cancers, inactivating mutations in upstream Hippo components...
4.
Seavey C, Hallett A, Li S, Che K, Pobbati A, Ma S, et al.
Clin Cancer Res
. 2023 Jan;
29(13):2480-2493.
PMID: 36598859
Purpose: Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma caused by the WWTR1(TAZ)-CAMTA1 (TC) gene fusion. This fusion gene has been observed in almost all reported EHE cases and functions as...
5.
Seavey C, Pobbati A, Rubin B
Cancers (Basel)
. 2022 Jun;
14(12).
PMID: 35740643
The activities of YAP and TAZ, the end effectors of the Hippo pathway, are consistently altered in cancer, and this dysregulation drives aggressive tumor phenotypes. While the actions of these...
6.
Ma S, Kanai R, Pobbati A, Li S, Che K, Seavey C, et al.
Clin Cancer Res
. 2022 Apr;
28(14):3116-3126.
PMID: 35443056
Purpose: A consistent genetic alteration in vascular cancer epithelioid hemangioendothelioma (EHE) is the t(1;3)(p36;q25) chromosomal translocation, which generates a WWTR1(TAZ)-CAMTA1 (TC) fusion gene. TC is a transcriptional coactivator that drives...
7.
Che K, Pobbati A, Seavey C, Fedorov Y, Komar A, Burtscher A, et al.
PLoS One
. 2022 Apr;
17(4):e0266143.
PMID: 35417479
Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here,...
8.
Gupta A, Ma S, Che K, Pobbati A, Rubin B
PLoS One
. 2021 Jul;
16(7):e0252689.
PMID: 34324512
Activating mutations in KIT/PDGFRA receptor tyrosine kinases drive gastrointestinal stromal tumors (GIST). KIT/PDGFRA inhibitors, such as imatinib do not evoke an effective cytocidal response, leaving room for quiescence and development...
9.
Gibault F, Sturbaut M, Coevoet M, Pugniere M, Burtscher A, Allemand F, et al.
ChemMedChem
. 2021 May;
16(18):2823-2844.
PMID: 34032019
Starting from our previously reported hit, a series of 1,5-diaryl-1,2,3-triazole-4-carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ-TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetry,...
10.
Seavey C, Pobbati A, Hallett A, Ma S, Reynolds J, Kanai R, et al.
Genes Dev
. 2021 Mar;
35(7-8):512-527.
PMID: 33766982
Epithelioid hemangioendothelioma (EHE) is a genetically homogenous vascular sarcoma that is a paradigm for TAZ dysregulation in cancer. EHE harbors a (TAZ)- gene fusion in >90% of cases, 45% of...