Agripina G Deaciuc
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Explore the profile of Agripina G Deaciuc including associated specialties, affiliations and a list of published articles.
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17
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180
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Recent Articles
1.
Marusich J, Darna M, George Wilson A, Denehy E, Ebben A, Deaciuc A, et al.
Eur J Pharmacol
. 2017 Aug;
814:196-206.
PMID: 28844873
Tobacco products are some of the most commonly used psychoactive drugs worldwide. Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific investigation of these constituents and their contribution...
2.
Ding D, Nickell J, Deaciuc A, Penthala N, Dwoskin L, Crooks P
Bioorg Med Chem
. 2013 Sep;
21(21):6771-7.
PMID: 23993667
Lobelane analogs that incorporate a central piperidine or pyrrolidine moiety have previously been reported by our group as potent inhibitors of VMAT2 function. Further central ring size reduction of the...
3.
Penthala N, Ponugoti P, Nickell J, Deaciuc A, Dwoskin L, Crooks P
Bioorg Med Chem Lett
. 2013 Apr;
23(11):3342-5.
PMID: 23597792
Central heterocyclic ring size reduction from piperidinyl to pyrrolidinyl in the vesicular monoamine transporter-2 (VMAT2) inhibitor GZ-793A and its analogs resulted in novel N-propane-1,2(R)-diol analogs 11a-i. These compounds were evaluated...
4.
Zheng G, Horton D, Penthala N, Nickell J, Culver J, Deaciuc A, et al.
Medchemcomm
. 2013 Mar;
4(3):564-568.
PMID: 23527317
A series of -substituted lobelane analogues was synthesized and evaluated for their [H]dihydrotetrabenazine binding affinity at the vesicular monoamine transporter and for their inhibition of vesicular [H]dopamine uptake. Compound 19a,...
5.
Horton D, Siripurapu K, Norrholm S, Culver J, Hojahmat M, Beckmann J, et al.
J Pharmacol Exp Ther
. 2010 Dec;
336(3):940-51.
PMID: 21177475
Lobeline, a nicotinic receptor antagonist and neurotransmitter transporter inhibitor, is a candidate pharmacotherapy for methamphetamine abuse. meso-Transdiene (MTD), a lobeline analog, lacks nicotinic receptor affinity, retains affinity for vesicular monoamine...
6.
Nickell J, Zheng G, Deaciuc A, Crooks P, Dwoskin L
J Pharmacol Exp Ther
. 2010 Sep;
336(3):724-33.
PMID: 20876747
Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To increase selectivity for VMAT2, chemically defunctionalized lobeline analogs, including lobelane, were designed to eliminate...
7.
Zheng G, Dwoskin L, Deaciuc A, Crooks P
J Org Chem
. 2010 Jun;
74(16):6072-6.
PMID: 20560567
An efficient and highly stereocontrolled approach for the synthesis of the quinuclidine incorporated lobelane analogues, endo,endo- and exo,exo-2,6-cis-diphenethyl-1-azabicyclo-[2.2.2]octane (2 and 3), has been developed. Analogues 2 and 3 were designed...
8.
Zheng G, Dwoskin L, Deaciuc A, Crooks P
Bioorg Med Chem Lett
. 2008 Nov;
18(24):6509-12.
PMID: 18976906
A series of lobelane homologues has been synthesized and evaluated for their [(3)H]DTBZ binding affinity at the vesicular monoamine transporter-2 (VMAT2). The structure-activity relationships (SAR) indicate that for retention of...
9.
Dwoskin L, Wooters T, Sumithran S, Siripurapu K, Joyce B, Lockman P, et al.
J Pharmacol Exp Ther
. 2008 May;
326(2):563-76.
PMID: 18460644
The current study evaluated a new series of N,N'-alkane-diyl-bis-3-picolinium (bAPi) analogs with C6-C12 methylene linkers as nicotinic acetylcholine receptor (nAChR) antagonists, for nicotine-evoked [3H]dopamine (DA) overflow, for blood-brain barrier choline...
10.
Zheng G, Zhang Z, Pivavarchyk M, Deaciuc A, Dwoskin L, Crooks P
Bioorg Med Chem Lett
. 2007 Nov;
17(24):6734-8.
PMID: 18029180
A series of conformationally restricted bis-azaaromatic quaternary ammonium salts (3 and 4) have been designed and synthesized in order to investigate the possible binding conformations of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB; 2),...