Afreen Inam
Overview
Explore the profile of Afreen Inam including associated specialties, affiliations and a list of published articles.
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8
Citations
36
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0
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Recent Articles
1.
Saifi Z, Ali A, Inam A, Azam A, Kamthan M, Abid M, et al.
RSC Adv
. 2025 Jan;
15(3):1680-1689.
PMID: 39831044
Antibiotic-resistant bacteria are a serious global health threat, making infections harder to treat and increasing medical costs and mortality rates. To combat resistant bacterial strains, a series of compounds (QS1-12)...
2.
Samreen S, Ali A, Ahmedi S, Raghib M, Haque A, Manzoor N, et al.
Antibiotics (Basel)
. 2025 Jan;
13(12.
PMID: 39766545
The increasing prevalence of antimicrobial resistant highlights the urgent need for the new therapeutic agents. This study aimed to design and synthesize fused tricyclic benzimidazole-thiazinone derivatives (-) through a convenient...
3.
Khan N, Khan P, Inam A, Ahmad K, Yousuf M, Islam A, et al.
RSC Adv
. 2022 May;
10(34):20129-20137.
PMID: 35520423
Microtubule affinity regulating kinase 4 (MARK4) is a Ser/Thr kinase, considered as a potential drug target for cancer, diabetes and neurodegenerative diseases. Due to its significant role in the development...
4.
Ansari M, Inam A, Ahmad K, Fatima S, Agarwal S, Azam A
Bioorg Med Chem Lett
. 2020 Sep;
30(23):127549.
PMID: 32927029
Metronidazole and its derivatives are widely used for the treatment of amoebiasis. However, metronidazole is considered as the standard drug but it has many side effects. The present study describes...
5.
Sharma G, Gurung S, Inam A, Nigam L, Bist A, Mohapatra D, et al.
Toxicol In Vitro
. 2019 Jun;
60:420-436.
PMID: 31175925
Metastatic prostate cancer, with no effective treatment, is among the leading causes of cancer-associated deaths in men. Overexpression of p38αMAPK has been observed in neuroendocrine prostate cancer patients and in...
6.
Ansari M, Hayat F, Inam A, Kathrada F, van Zyl R, Coetzee M, et al.
Bioorg Med Chem Lett
. 2016 Dec;
27(3):460-465.
PMID: 28027871
In an endeavor to develop efficacious antiprotozoal agents 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives (5-14) were synthesized, characterized and biologically evaluated for antiprotozoal activity. The compounds were screened in vitro against the HM1:...
7.
Inam A, Mittal S, Rajala M, Avecilla F, Azam A
Eur J Med Chem
. 2016 Sep;
124:445-455.
PMID: 27598233
In the quest for potent antiamoebic agents, a series of hydrazone hybrids (H1H30) have been designed and sequentially synthesized. The dimethylaminoethoxy and hydrazone entities incorporated into one molecule proved to...
8.
Inam A, Siddiqui S, Macedo T, Moreira D, Lima Leite A, Soares M, et al.
Eur J Med Chem
. 2014 Feb;
75:67-76.
PMID: 24530492
N-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and biologically evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica trophozoites. N-Acylhydrazone F12 was found to inhibit the P. falciparum growth as well...
9.
Salahuddin A, Inam A, van Zyl R, Heslop D, Chen C, Avecilla F, et al.
Bioorg Med Chem
. 2013 Apr;
21(11):3080-9.
PMID: 23602620
A new series of 4-aminochloroquinoline based sulfonamides were synthesized and evaluated for antiamoebic and antimalarial activities. Out of the eleven compounds evaluated (F1-F11), two of them (F3 and F10) showed...