Adrian J Thrasher
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Explore the profile of Adrian J Thrasher including associated specialties, affiliations and a list of published articles.
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333
Citations
14515
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Recent Articles
1.
Golwala Z, Spiridou Goncalves H, Moirangthem R, Evans G, Lizot S, de Koning C, et al.
Clin Immunol
. 2025 Feb;
274:110453.
PMID: 39965724
Persistent selective T-lymphocytopenia is found both in SCID and congenital athymia. Without molecular diagnosis, it is challenging to determine whether HCT or thymus transplantation ought to be performed. Ex vivo...
2.
Westhaus A, Barba-Sarasua E, Chen Y, Hsu K, Scott S, Knight M, et al.
Mol Ther
. 2024 Dec;
PMID: 39673125
Chimeric antigen receptor (CAR) T cell (CAR-T) therapies present options for patients diagnosed with certain leukemias. Recent advances of the technology included a method to integrate the CAR into the...
3.
Blanco E, Camps C, Bahal S, Kerai M, Ferla M, Rochussen A, et al.
J Exp Med
. 2024 Nov;
222(1).
PMID: 39560673
The importance of calcium (Ca2+) as a second messenger in T cell signaling is exemplified by genetic deficiencies of STIM1 and ORAI1, which abolish store-operated Ca2+ entry (SOCE) resulting in...
4.
Kwiatkowski J, Walters M, Hongeng S, Yannaki E, Kulozik A, Kunz J, et al.
Lancet
. 2024 Nov;
404(10468):2175-2186.
PMID: 39527960
Background: Transfusion-dependent β-thalassaemia (TDT) is a severe disease, resulting in lifelong blood transfusions, iron overload, and associated complications. Betibeglogene autotemcel (beti-cel) gene therapy uses autologous haematopoietic stem and progenitor cells...
5.
Eichler F, Duncan C, Musolino P, Lund T, Gupta A, Oliveira S, et al.
N Engl J Med
. 2024 Oct;
391(14):1302-1312.
PMID: 39383459
Background: Cerebral adrenoleukodystrophy is a severe form of X-linked adrenoleukodystrophy characterized by white-matter disease, loss of neurologic function, and early death. Elivaldogene autotemcel (eli-cel) gene therapy, which consists of autologous...
6.
Ha T, Morgan M, Thrasher A, Schambach A
Hum Gene Ther
. 2024 Aug;
35(17-18):669-679.
PMID: 39150017
Severe combined immunodeficiency (SCID) encompasses rare primary immunodeficiency disorders characterized by deficient T-cell development, which leads to a severely compromised immune system and susceptibility to life-threatening infections. Among SCID subtypes,...
7.
Moschidou D, Mukherjee S, Blundell M, Drews K, Jones G, Abdulrazzak H, et al.
Mol Ther
. 2024 Aug;
32(8):2798.
PMID: 39122329
No abstract available.
8.
Naviglio S, Cicalese M, Rivers E, Ferrua F, Bonfim C, Cenciarelli S, et al.
Blood
. 2024 Jul;
144(16):1699-1704.
PMID: 39046813
Up to 70% of patients with Wiskott-Aldrich syndrome (WAS) develop autoimmune and inflammatory manifestations. Dysregulation of interleukin 1 (IL-1) may be involved in their pathogenesis, yet there is little evidence...
9.
Yeung J, Liao A, Shaw M, Silva S, Vetharoy W, Rico D, et al.
Mol Ther
. 2024 Mar;
32(6):1672-1686.
PMID: 38549377
Stem cell gene therapy and hematopoietic stem cell transplantation (SCT) require conditioning to ablate the recipient's hematopoietic stem cells (HSCs) and create a niche for gene-corrected/donor HSCs. Conventional conditioning agents...
10.
Bahal S, Zinicola M, Moula S, Whittaker T, Schejtman A, Naseem A, et al.
J Allergy Clin Immunol
. 2024 Mar;
154(1):195-208.e8.
PMID: 38479630
Background: X-linked agammaglobulinemia (XLA) is an inborn error of immunity that renders boys susceptible to life-threatening infections due to loss of mature B cells and circulating immunoglobulins. It is caused...