Steven J Howe
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Explore the profile of Steven J Howe including associated specialties, affiliations and a list of published articles.
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40
Citations
1908
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Recent Articles
1.
Johnson C, Williams M, Sham K, Belluschi S, Ma W, Wang X, et al.
Blood
. 2024 May;
144(7):729-741.
PMID: 38805639
Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain...
2.
Chen Y, Pallant C, Sampson C, Boiti A, Johnson S, Brazauskas P, et al.
Mol Ther Methods Clin Dev
. 2020 Sep;
19:47-57.
PMID: 32995359
Stable suspension producer cell lines for the production of vesicular stomatitis virus envelope glycoprotein (VSVg)-pseudotyped lentiviral vectors represent an attractive alternative to current widely used production methods based on transient...
3.
Rittie L, Athanasopoulos T, Calero-Garcia M, Davies M, Dow D, Howe S, et al.
Mol Ther
. 2019 Sep;
27(10):1706-1717.
PMID: 31526597
The field of cell and gene therapy (GT) is expanding rapidly and there is undoubtedly a wave of enthusiasm and anticipation for what these treatments could achieve next. Here we...
4.
Lambert J, Howe S, Rahim A, Burke D, Heales S
Int J Mol Sci
. 2019 Sep;
20(18.
PMID: 31491876
Fabry disease (FD) is caused by mutations in the gene that encodes lysosomal α-galactosidase-A (α-gal-A). A number of pathogenic mechanisms have been proposed and these include loss of mitochondrial respiratory...
5.
Counsell J, Karda R, Diaz J, Carey L, Wiktorowicz T, Buckley S, et al.
Mol Ther Nucleic Acids
. 2018 Aug;
12:626-634.
PMID: 30081233
Viral vectors are rapidly being developed for a range of applications in research and gene therapy. Prototype foamy virus (PFV) vectors have been described for gene therapy, although their use...
6.
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T
Sci Rep
. 2017 Oct;
7(1):12475.
PMID: 28963568
The generation of T cells from pluripotent stem cells (PSCs) is attractive for investigating T cell development and validating genome editing strategies in vitro. X-linked severe combined immunodeficiency (X-SCID) is...
7.
Alonso-Ferrero M, van Til N, Bartolovic K, Mata M, Wagemaker G, Moulding D, et al.
Exp Hematol
. 2017 Sep;
57:21-29.
PMID: 28911908
Integration-deficient lentiviruses (IdLVs) deliver genes effectively to tissues but are lost rapidly from dividing cells. This property can be harnessed to express transgenes transiently to manipulate cell biology. Here, we...
8.
Counsell J, Asgarian Z, Meng J, Ferrer V, Vink C, Howe S, et al.
Sci Rep
. 2017 Aug;
7:46880.
PMID: 28849794
This corrects the article DOI: 10.1038/srep44775.
9.
Vink C, Counsell J, Perocheau D, Karda R, Buckley S, Brugman M, et al.
Mol Ther
. 2017 May;
25(8):1790-1804.
PMID: 28550974
Lentiviral vector genomic RNA requires sequences that partially overlap wild-type HIV-1 gag and env genes for packaging into vector particles. These HIV-1 packaging sequences constitute 19.6% of the wild-type HIV-1...
10.
Counsell J, Asgarian Z, Meng J, Ferrer V, Vink C, Howe S, et al.
Sci Rep
. 2017 Mar;
7:44775.
PMID: 28303972
Duchenne Muscular Dystrophy (DMD) is caused by a lack of dystrophin expression in patient muscle fibres. Current DMD gene therapy strategies rely on the expression of internally deleted forms of...