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Waseem Qasim

Explore the profile of Waseem Qasim including associated specialties, affiliations and a list of published articles. Areas
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Articles 106
Citations 3273
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Recent Articles
1.
Georgiadis C, Nickolay L, Syed F, Zhan H, Gkazi S, Etuk A, et al.
Haematologica . 2024 Jul; 109(12):3941-3951. PMID: 38988258
Umbilical cord blood (UCB) T cells exhibit distinct naïve ontogenetic profiles and may be an attractive source of starting cells for the production of chimeric antigen receptor (CAR) T cells....
2.
Bonini C, Chapuis A, Hudecek M, Guedan S, Magnani C, Qasim W
Hum Gene Ther . 2023 Sep; 34(17-18):853-869. PMID: 37694593
Advanced gene transfer technologies and profound immunological insights have enabled substantial increases in the efficacy of anticancer adoptive cellular therapy (ACT). In recent years, the U.S. Food and Drug Administration...
3.
Chiesa R, Georgiadis C, Syed F, Zhan H, Etuk A, Gkazi S, et al.
N Engl J Med . 2023 Jun; 389(10):899-910. PMID: 37314354
Background: Cytidine deamination that is guided by clustered regularly interspaced short palindromic repeats (CRISPR) can mediate a highly precise conversion of one nucleotide into another - specifically, cytosine to thymine...
4.
Naso G, Gkazi S, Georgiadis C, Jayarajan V, Jackow J, Fleck R, et al.
JID Innov . 2023 May; 3(3):100191. PMID: 37213713
Recessive dystrophic epidermolysis bullosa is a debilitating blistering skin disorder caused by loss-of-function mutations in which encodes type VII collagen, the main component of anchoring fibrils at the dermal-epidermal junction....
5.
Golwala Z, Bhat N, Xu-Bayford J, Stankova T, Adams S, Morris E, et al.
J Clin Immunol . 2023 Mar; 43(5):1019-1031. PMID: 36930409
Purpose: There is a lack of data on post-HSCT non-osteopenic bone pathology specifically for children with inborn errors of immunity (IEI). We collected data on non-osteopenic bone pathology in children...
6.
Ottaviano G, Georgiadis C, Gkazi S, Syed F, Zhan H, Etuk A, et al.
Sci Transl Med . 2022 Oct; 14(668):eabq3010. PMID: 36288281
Genome editing of allogeneic T cells can provide "off-the-shelf" alternatives to autologous chimeric antigen receptor (CAR) T cell therapies. Disruption of T cell receptor α chain (TRAC) to prevent graft-versus-host...
7.
Qasim W
Blood . 2022 Oct; 141(8):835-845. PMID: 36223560
αβ T cell receptor (TCRαβ) T cells modified to express chimeric antigen receptors (CAR), are now available as authorized therapies for certain B-cell malignancies. However the process of autologous harvest...
8.
Ottaviano G, Qasim W
Hematol Oncol Clin North Am . 2022 Jun; 36(4):729-744. PMID: 35773047
Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing platforms...
9.
Qasim W
Gene Genome Ed . 2022 Jan; 2:None. PMID: 34977824
The potential of engineered TCRαβ T cells as potent mediators of leukemic clearance has been demonstrated in clinical trials, and authorised therapies are being deployed against B cell malignancies in...
10.
Rota I, Handel A, Maio S, Klein F, Dhalla F, Deadman M, et al.
Sci Adv . 2021 Dec; 7(49):eabj9247. PMID: 34860543
The transcription factor FOXN1 is a master regulator of thymic epithelial cell (TEC) development and function. Here, we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in...