Adrian D Bonev
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Explore the profile of Adrian D Bonev including associated specialties, affiliations and a list of published articles.
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46
Citations
2497
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Recent Articles
1.
Sancho M, Klug N, Mughal A, Koide M, Huerta de la Cruz S, Heppner T, et al.
Sci Signal
. 2022 Mar;
15(727):eabl5405.
PMID: 35349300
The dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron- and glial-derived compounds that...
2.
Sackheim A, Villalba N, Sancho M, Harraz O, Bonev A, DAlessandro A, et al.
Function (Oxf)
. 2021 Sep;
2(3).
PMID: 34568829
Trauma can lead to widespread vascular dysfunction, but the underlying mechanisms remain largely unknown. Inward-rectifier potassium channels (Kir2.1) play a critical role in the dynamic regulation of regional perfusion and...
3.
Turco A, Oakes S, Keil Stietz K, Dunham C, Joseph D, Chathurvedula T, et al.
Dis Model Mech
. 2021 Jul;
14(7).
PMID: 34318329
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we...
4.
Collier D, Villalba N, Sackheim A, Bonev A, Miller Z, Moore J, et al.
Am J Physiol Heart Circ Physiol
. 2019 Mar;
316(6):H1309-H1322.
PMID: 30848676
Histone proteins are elevated in the circulation after traumatic injury owing to cellular lysis and release from neutrophils. Elevated circulating histones in trauma contribute to coagulopathy and mortality through a...
5.
Tykocki N, Heppner T, Dalsgaard T, Bonev A, Nelson M
J Physiol
. 2018 Dec;
597(3):935-950.
PMID: 30536555
Key Points: K 7 channels are a family of voltage-dependent K channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that...
6.
Sheehe J, Bonev A, Schmoker A, Ballif B, Nelson M, Moon T, et al.
J Biol Chem
. 2018 Sep;
293(43):16791-16802.
PMID: 30206122
The type I cGMP-dependent protein kinase (PKG I) is an essential regulator of vascular tone. It has been demonstrated that the type Iα isoform can be constitutively activated by oxidizing...
7.
Baylie R, Ahmed M, Bonev A, Hill-Eubanks D, Heppner T, Nelson M, et al.
Physiol Rep
. 2017 Aug;
5(16).
PMID: 28830977
The aim of this study was to investigate mechanisms by which adiponectin influences vascular Ca signaling, K channel activity and thus contractile tone of small arteries. Vasodilation to adiponectin was...
8.
Tykocki N, Bonev A, Longden T, Heppner T, Nelson M
Am J Physiol Renal Physiol
. 2017 Feb;
312(5):F836-F847.
PMID: 28148533
Prolonged decreases in urinary bladder blood flow are linked to overactive and underactive bladder pathologies. However, the mechanisms regulating bladder vascular reactivity are largely unknown. To investigate these mechanisms, we...
9.
Khavandi K, Baylie R, Sugden S, Ahmed M, Csato V, Eaton P, et al.
Sci Signal
. 2016 Oct;
9(449):ra100.
PMID: 27729550
Activation of Ca-sensitive, large-conductance potassium (BK) channels in vascular smooth muscle cells (VSMCs) by local, ryanodine receptor-mediated Ca signals (Ca sparks) acts as a brake on pressure-induced (myogenic) vasoconstriction-a fundamental...
10.
Povlsen G, Longden T, Bonev A, Hill-Eubanks D, Nelson M
J Cereb Blood Flow Metab
. 2016 Apr;
36(7):1195-201.
PMID: 27052838
Transient global cerebral ischemia is often followed by delayed disturbances of cerebral blood flow, contributing to neuronal injury. The pathophysiological processes underlying such disturbances are incompletely understood. Here, using an...