Adrian Britschgi
Overview
Explore the profile of Adrian Britschgi including associated specialties, affiliations and a list of published articles.
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20
Citations
879
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Recent Articles
1.
Vulin M, Jehanno C, Sethi A, Correia A, Obradovic M, Couto J, et al.
Oncogene
. 2022 Aug;
41(39):4459-4473.
PMID: 36008466
Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast cancer, the subtype triple-negative lacks expression of major differentiation markers, e.g., estrogen receptor α (ERα), and its high...
2.
Britschgi A, Couto J, Bentires-Alj M
Nature
. 2021 Mar;
591(7848):E11-E12.
PMID: 33658689
No abstract available.
3.
Ottis P, Palladino C, Thienger P, Britschgi A, Heichinger C, Berrera M, et al.
ACS Chem Biol
. 2019 Sep;
14(10):2215-2223.
PMID: 31553577
Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by proteasome-mediated degradation. The first...
4.
Jin J, Britschgi A, Schlafli A, Humbert M, Shan-Krauer D, Batliner J, et al.
Oxid Med Cell Longev
. 2018 May;
2018:1482795.
PMID: 29743969
Autophagy is an intracellular degradation system that ensures a dynamic recycling of a variety of building blocks required for self-renewal, homeostasis, and cell survival under stress. We used primary acute...
5.
Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al.
Nature
. 2017 Jan;
541(7638):541-545.
PMID: 28068668
Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated...
6.
Geering B, Zokouri Z, Hurlemann S, Gerrits B, Auslander D, Britschgi A, et al.
Mol Cell Biol
. 2015 Oct;
36(1):132-43.
PMID: 26483415
Death-associated protein kinase 2 (DAPK2) is a Ca(2+)/calmodulin-dependent Ser/Thr kinase that possesses tumor-suppressive functions and regulates programmed cell death, autophagy, oxidative stress, hematopoiesis, and motility. As only few binding partners...
7.
Koren S, Reavie L, Couto J, De Silva D, Stadler M, Roloff T, et al.
Nature
. 2015 Aug;
525(7567):114-8.
PMID: 26266975
The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative...
8.
Orfali N, ODonovan T, Nyhan M, Britschgi A, Tschan M, Cahill M, et al.
Exp Hematol
. 2015 May;
43(9):781-93.e2.
PMID: 25986473
Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic...
9.
Duss S, Brinkhaus H, Britschgi A, Cabuy E, Frey D, Schaefer D, et al.
Breast Cancer Res
. 2014 Jun;
16(3):R60.
PMID: 24916766
Introduction: Stromal-epithelial interactions play a fundamental role in tissue homeostasis, controlling cell proliferation and differentiation. Not surprisingly, aberrant stromal-epithelial interactions contribute to malignancies. Studies of the cellular and molecular mechanisms...
10.
Britschgi A, Radimerski T, Bentires-Alj M
Drug Resist Updat
. 2013 Oct;
16(3-5):68-72.
PMID: 24169539
The widespread hyperactivation of the PI3K/mTOR pathway in human cancer has made it a prime target for the treatment of this disease. However, a variety of resistance mechanisms involving (re)activation...