Adrian Britschgi
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Explore the profile of Adrian Britschgi including associated specialties, affiliations and a list of published articles.
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20
Citations
879
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Recent Articles
11.
Humbert M, Federzoni E, Britschgi A, Schlafli A, Valk P, Kaufmann T, et al.
J Leukoc Biol
. 2013 Sep;
95(1):83-93.
PMID: 24038216
DAPK2 is a proapoptotic protein that is mostly expressed in the hematopoietic tissue. A detailed DAPK2 expression analysis in two large AML patient cohorts revealed particularly low DAPK2 mRNA levels...
12.
Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(11):E1026-34.
PMID: 23431153
The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer, but its functional role in tumorigenesis...
13.
Britschgi A, Andraos R, Brinkhaus H, Klebba I, Romanet V, Muller U, et al.
Cancer Cell
. 2012 Dec;
22(6):796-811.
PMID: 23238015
Hyperactive PI3K/mTOR signaling is prevalent in human malignancies and its inhibition has potent antitumor consequences. Unfortunately, single-agent targeted cancer therapy is usually short-lived. We have discovered a JAK2/STAT5-evoked positive feedback...
14.
Duss S, Britschgi A, Bentires-Alj M
Breast Cancer Res
. 2012 Aug;
14(4):318.
PMID: 22866917
The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In...
15.
Balavenkatraman K, Aceto N, Britschgi A, Mueller U, Bence K, Neel B, et al.
Mol Cancer Res
. 2011 Aug;
9(10):1377-84.
PMID: 21849469
Protein-tyrosine phosphatase 1B (PTP1B), a well-established metabolic regulator, plays an important role in breast cancer. Using whole-body PTP1B knockout mice, recent studies have shown that PTP1B ablation delays HER2/Neu-induced mammary...
16.
Britschgi A, Simon H, Tobler A, Fey M, Tschan M
Br J Haematol
. 2010 Jan;
149(1):55-64.
PMID: 20096012
Acute promyelocytic leukaemia (APL) patients are successfully treated with all-trans retinoic acid (ATRA). However, concurrent chemotherapy is still necessary and less toxic therapeutic approaches are needed. Earlier studies suggested that...
17.
Jenal M, Trinh E, Britschgi C, Britschgi A, Roh V, Vorburger S, et al.
Mol Cancer Res
. 2009 Jun;
7(6):916-22.
PMID: 19491197
The Hypermethylated in Cancer 1 (HIC1) gene encodes a zinc finger transcriptional repressor that cooperates with p53 to suppress cancer development. We and others recently showed that HIC1 is a...
18.
Urbach D, Britschgi A, Jacob A, Bittner D, Bernet D, Wahli T, et al.
Dis Aquat Organ
. 2008 Oct;
81(2):119-25.
PMID: 18924376
In recent years, numerous cases of morphological gonadal alterations in fish have been recorded throughout the world and across a wide range of species. In the whitefish Coregonus fatioi from...
19.
Jacob A, Nussle S, Britschgi A, Evanno G, Muller R, Wedekind C
BMC Evol Biol
. 2007 Nov;
7:207.
PMID: 17974038
Background: Males that are successful in intra-sexual competition are often assumed to be of superior quality. In the mating system of most salmonid species, intensive dominance fights are common and...
20.
Rizzi M, Tschan M, Britschgi C, Britschgi A, Hugli B, Grob T, et al.
J Leukoc Biol
. 2007 Mar;
81(6):1599-608.
PMID: 17347302
The death-associated protein kinase 2 (DAPK2) belongs to a family of Ca(2+)/calmodulin-regulated serine/threonine kinases involved in apoptosis. During investigation of candidate genes operative in granulopoiesis, we identified DAPK2 as highly...