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Stephan Duss

Explore the profile of Stephan Duss including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 872
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Recent Articles
1.
Britschgi A, Duss S, Kim S, Couto J, Brinkhaus H, Koren S, et al.
Nature . 2017 Jan; 541(7638):541-545. PMID: 28068668
Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated...
2.
Villasenor R, Miraglia L, Romero A, Tu B, Punga T, Knuckles P, et al.
J Biomol Screen . 2015 Jan; 20(6):760-7. PMID: 25616511
Friedreich's ataxia is a neurodegenerative disease caused by deficiency of the mitochondrial protein frataxin. This deficiency results from expansion of a trinucleotide repeat in the first intron of the frataxin...
3.
Duss S, Brinkhaus H, Britschgi A, Cabuy E, Frey D, Schaefer D, et al.
Breast Cancer Res . 2014 Jun; 16(3):R60. PMID: 24916766
Introduction: Stromal-epithelial interactions play a fundamental role in tissue homeostasis, controlling cell proliferation and differentiation. Not surprisingly, aberrant stromal-epithelial interactions contribute to malignancies. Studies of the cellular and molecular mechanisms...
4.
Huck B, Duss S, Hausser A, Olayioye M
J Biol Chem . 2013 Dec; 289(6):3138-47. PMID: 24337579
Here, we show that the expression of the Golgi-localized serine-threonine kinase protein kinase D3 (PKD3) is elevated in triple-negative breast cancer (TNBC). Using an antibody array, we identified PKD3 to...
5.
Alajati A, Sausgruber N, Aceto N, Duss S, Sarret S, Voshol H, et al.
Cancer Res . 2013 Jul; 73(17):5320-7. PMID: 23867476
The HER2 gene is amplified and overexpressed in approximately 20% of invasive breast cancers where it is associated with metastasis and poor prognosis. Here, we describe a constitutively active splice...
6.
Meier-Abt F, Milani E, Roloff T, Brinkhaus H, Duss S, Meyer D, et al.
Breast Cancer Res . 2013 Apr; 15(2):R36. PMID: 23621987
Introduction: Early pregnancy has a strong protective effect against breast cancer in humans and rodents, but the underlying mechanism is unknown. Because breast cancers are thought to arise from specific...
7.
Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, et al.
Proc Natl Acad Sci U S A . 2013 Feb; 110(11):E1026-34. PMID: 23431153
The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer, but its functional role in tumorigenesis...
8.
Aceto N, Duss S, MacDonald G, Meyer D, Roloff T, Hynes N, et al.
Breast Cancer Res . 2012 Oct; 14(5):R131. PMID: 23062209
Introduction: The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall...
9.
Duss S, Britschgi A, Bentires-Alj M
Breast Cancer Res . 2012 Aug; 14(4):318. PMID: 22866917
The Hippo pathway has emerged as a well-conserved kinase cascade controlling cell proliferation and survival and has recently gained much attention for its key activity as a tumor suppressor. In...
10.
Heering J, Weis N, Holeiter M, Neugart F, Staebler A, Fehm T, et al.
Cancer Res . 2012 Apr; 72(11):2855-66. PMID: 22472120
Triple-negative breast cancers (TNBC) are especially refractory to treatment due to their negative hormone receptor and ErbB2/HER2 status. Therefore, the identification of cancer-associated deregulated signaling pathways is necessary to develop...