Adel F M Ibrahim
Overview
Explore the profile of Adel F M Ibrahim including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
932
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Recent Articles
1.
Liczmanska M, Tatham M, Mojsa B, Eugui-Anta A, Rojas-Fernandez A, Ibrahim A, et al.
Cell Rep
. 2023 Aug;
42(8):112960.
PMID: 37556322
The small ubiquitin-like modifier (SUMO) protease SENP6 disassembles SUMO chains from cellular substrate proteins. We use a proteomic method to identify putative SENP6 substrates based on increased apparent molecular weight...
2.
Ibrahim A, Shen L, Tatham M, Dickerson D, Prescott A, Abidi N, et al.
Mol Cell
. 2020 May;
79(1):155-166.e9.
PMID: 32454028
To understand gene function, the encoding DNA or mRNA transcript can be manipulated and the consequences observed. However, these approaches do not have a direct effect on the protein product...
3.
McHugh A, Fernandes K, Chinner N, Ibrahim A, Garg A, Boag G, et al.
J Invest Dermatol
. 2019 Nov;
140(6):1154-1165.e5.
PMID: 31705877
We performed a small interfering RNA screen to identify targets for cutaneous squamous cell carcinoma (cSCC) therapy in the ubiquitin/ubiquitin-like system. We provide evidence for selective anti-cSCC activity of knockdown...
4.
Rabl J, Bunker R, Schenk A, Cavadini S, Gill M, Abdulrahman W, et al.
Mol Cell
. 2019 Jun;
75(3):483-497.e9.
PMID: 31253574
In mammals, ∼100 deubiquitinases act on ∼20,000 intracellular ubiquitination sites. Deubiquitinases are commonly regarded as constitutively active, with limited regulatory and targeting capacity. The BRCA1-A and BRISC complexes serve in...
5.
Tammsalu T, Matic I, Jaffray E, Ibrahim A, Tatham M, Hay R
Nat Protoc
. 2015 Aug;
10(9):1374-88.
PMID: 26292070
The protein called 'small ubiquitin-like modifier' (SUMO) is post-translationally linked to target proteins at the ɛ-amino group of lysine residues. This 'SUMOylation' alters the behavior of the target protein, a...
6.
Bett J, Ibrahim A, Garg A, Rocha S, Hay R
J Vis Exp
. 2014 Jun;
(87).
PMID: 24893647
Post-translational modification of proteins with ubiquitin and ubiquitin-like molecules (UBLs) is emerging as a dynamic cellular signaling network that regulates diverse biological pathways including the hypoxia response, proteostasis, the DNA...
7.
Tammsalu T, Matic I, Jaffray E, Ibrahim A, Tatham M, Hay R
Sci Signal
. 2014 May;
7(323):rs2.
PMID: 24782567
Posttranslational modification with small ubiquitin-like modifiers (SUMOs) alters the function of proteins involved in diverse cellular processes. SUMO-specific enzymes conjugate SUMOs to lysine residues in target proteins. Although proteomic studies...
8.
MacKay C, Carroll E, Ibrahim A, Garg A, Inman G, Hay R, et al.
Cancer Res
. 2014 Apr;
74(8):2246-2257.
PMID: 24686174
The genotoxin cisplatin is commonly used in chemotherapy to treat solid tumors, yet our understanding of the mechanism underlying the drug response is limited. In a focused siRNA screen, using...
9.
Poncet N, Mitchell F, Ibrahim A, McGuire V, English G, Arthur J, et al.
PLoS One
. 2014 Mar;
9(2):e89547.
PMID: 24586861
The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K...
10.
Fang W, Du T, Raimi O, Hurtado-Guerrero R, Marino K, Ibrahim A, et al.
Biosci Rep
. 2013 Jul;
33(5).
PMID: 23844980
Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesized by processive glycosyltransferases...